ICRF-193 CAS: 21416-68-2
MF: C12H18N4O4
MW: 282.30
A bisdioxopiperazine which induces apoptosis and erythroid differentiation.

ICRF-193 (CAS 21416-68-2)

ICRF-193 | CAS 21416-68-2 is rated 5.0 out of 5 by 1.
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Synonym: 4,4'-(1,2-Dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione
Application: A bisdioxopiperazine which induces apoptosis and erythroid differentiation
CAS Number: 21416-68-2
Purity: ≥95%
Molecular Weight: 282.30
Molecular Formula: C12H18N4O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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ICRF-193, a bisdioxopiperazine, is a catalytic noncleavable complex-forming inhibitor of DNA Topo II (topoisomerase II) that does not produce protein-linked DNA strand breaks. This compound has been shown to induce erythroid differentiation and apoptosis. Mechanistic studies suggest that ICRF-193 affects the caspase-3 activation/cleavage pathway of cell growth and associates with ATR-dependent inhibition of polo-like kinase (plk) 1 kinase activity and a decrease in cyclin B1 phosphorylation. ICRF-193 is an inhibitor of Topo II beta.


References

1. Iguchi, K., et al. 1999. Biochem. Pharmacol. 57: 1105-1111. PMID: 11230797
2. Hasinoff, B.B., et al. 2001. Mol. Pharmacol. 59: 453-461. PMID: 11179439
3. Deming, P.B., et al. 2002. J. Biol. Chem. 277: 36832-36838. PMID: 12147700
4. Hajji, N., et al. 2003. Mutat. Res. 530: 35-46. PMID: 14563529
5. Park, I. and Avraham, H.K. 2006. Exp. Cell Res. 312: 1996-2008. PMID: 16630610

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (4 mg/ml).
Storage :
Store at -20° C
Melting Point :
301.66° C (Predicted)
Boiling Point :
526.73° C at 760 mmHg (Predicted)
Density :
1.31 g/cm3 (Predicted)
Refractive Index :
n20D 1.54
IC50 :
DNA topoisomerase II alpha: IC50 = 13.9 µM (Homo sapiens); DNA topoisomerase II beta: IC50 = 13.9 µM (Homo sapiens)
pK Values :
pKa: 10.699, pKb: 2.953
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TL6380200
PubChem CID :
115150
MDL Number :
MFCD01702964
SMILES :
CC(C(C)N1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2

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Certificate of Analysis

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ICRF-193  Product Citations

See how others have used ICRF-193. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 31270138  2019. J. Cell Biol. 218: 2492-2513.

PMID: # 29765039  2018. Nat Commun. 9: 1908.

PMID: # 27829144  Su, KC. et al. 2016. Cell Rep. 17: 1728-1738.

PMID: # 26518113  Yan, YX. et al. 2015. Eur. J. Cell Biol. 94: 626-41.

PMID: # 24324754  Lambert, LJ. et al. 2013. PloS one. 8: e82110.

PMID: # 23995680  King, IF. et al. 2013. Nature. 501: 58-62.

Citations 1 to 6 of 6 total
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Rated 5 out of 5 by from Jain CK; et al Jain CK; et al. (PubMed: 25746763) determined ICRF193 to be a promising therapeutic agent for the treatment of colon cancers with a faulty DNA decatenation checkpoint. -SCBT Publication Review
Date published: 2015-04-28
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