IL-5R Inhibitors
IL-5R inhibitors are a class of chemical compounds designed to specifically target and inhibit the IL-5 receptor (IL-5R), a receptor complex located on the surface of certain immune cells, primarily eosinophils and basophils. The IL-5 receptor is composed of an alpha chain (IL-5Rα) that binds to interleukin-5 (IL-5), a cytokine responsible for regulating the growth, differentiation, and activation of these immune cells. When IL-5 binds to its receptor, it triggers a signaling cascade that promotes the survival and activation of eosinophils, playing a significant role in the immune response. By inhibiting IL-5R, these compounds prevent IL-5 from activating its receptor, thereby blocking the downstream signaling pathways that regulate eosinophil activity and function.
In research, IL-5R inhibitors provide critical insights into the role of the IL-5 receptor in immune cell regulation and the broader immune response. By blocking IL-5R, scientists can explore how inhibiting the receptor affects the behavior of eosinophils and basophils, offering a better understanding of how these cells contribute to various physiological processes, such as inflammation, immune cell recruitment, and cytokine production. Additionally, IL-5R inhibitors help researchers study the interactions between IL-5 and other cytokines or signaling molecules, revealing how the IL-5 receptor fits into the broader network of immune regulation. These inhibitors are valuable tools for dissecting the molecular mechanisms governing immune cell activation and for identifying how IL-5R-related pathways contribute to maintaining immune system balance in response to environmental or internal signals.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lenalidomide | 191732-72-6 | sc-218656 sc-218656A sc-218656B | 10 mg 100 mg 1 g | $49.00 $367.00 $2030.00 | 18 | |
Lenalidomide may downregulate IL-5R expression through inhibition of angiogenic and inflammatory cytokine production, which could disrupt the signaling pathways that normally increase IL-5R levels on eosinophils. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $109.00 $350.00 | 8 | |
Thalidomide could decrease IL-5R expression by reducing tumor necrosis factor alpha (TNF-α), a cytokine that can elevate IL-5R expression as part of an inflammatory response. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea might reduce IL-5R expression by curtailing ribonucleotide reductase activity, leading to a decrease in DNA synthesis and subsequent inhibition of cellular proliferation where IL-5R is overexpressed. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate may lead to a decrease in IL-5R expression by inhibiting the enzyme dihydrofolate reductase, resulting in reduced folate and nucleotide synthesis crucial for the proliferation of IL-5R-expressing cells. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone has the potential to inhibit IL-5R expression by activating glucocorticoid receptors, which can suppress the transcription of genes involved in the inflammatory response, including those responsible for IL-5R expression. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $41.00 | 4 | |
Aspirin may lead to the reduction of IL-5R expression by inhibiting the cyclooxygenase enzymes COX-1 and COX-2, leading to a decrease in prostaglandin production, which can diminish inflammatory signaling that upregulates IL-5R. | ||||||
Zileuton | 111406-87-2 | sc-204417 sc-204417A sc-204417B sc-204417C | 10 mg 50 mg 1 g 75 g | $82.00 $301.00 $362.00 $1229.00 | 8 | |
Zileuton could downregulate IL-5R expression by inhibiting 5-lipoxygenase, thereby reducing the synthesis of leukotrienes, which are involved in promoting inflammation and potentially upregulating IL-5R expression. | ||||||
Prednisolone | 50-24-8 | sc-205815 sc-205815A | 1 g 5 g | $82.00 $248.00 | 2 | |
Prednisolone could inhibit IL-5R expression by binding to glucocorticoid receptors, leading to transrepression of pro-inflammatory genes and a subsequent decrease in IL-5R expression. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A may decrease IL-5R expression by inhibiting calcineurin, which is necessary for the transcription of IL-2 and other cytokines that support the proliferation of IL-5R-expressing cells. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $60.00 $75.00 $125.00 $205.00 | 8 | |
Sulfasalazine might inhibit IL-5R expression by reducing the activation of the NF-κB pathway, which is known to control the transcription of various pro-inflammatory genes, including those involved in the expression of IL-5R. | ||||||