IL-5R Activators
The interleukin-5 receptor, commonly abbreviated as IL-5R, is a specialized protein complex found on the surface of certain cells within the immune system. It is primarily expressed on eosinophils, a type of white blood cell that plays a crucial role in the body's defense mechanisms, particularly in allergic responses and asthma. The receptor is composed of two subunits: the alpha chain, which binds the interleukin-5 (IL-5) molecule, and the beta chain, which is shared with the receptors for other cytokines such as IL-3 and GM-CSF. The interaction of IL-5 with its receptor is a pivotal step in the survival, proliferation, and activation of eosinophils. The regulation of IL-5R expression is a sophisticated process influenced by various internal and external factors, and understanding this regulation is important for elucidating the complex network of immune system responses.
Several chemical compounds are known to play a role in the cellular pathways that can potentially lead to the upregulation of IL-5R expression. These activators are diverse in their structure and function and may exert their effects through different mechanisms. For example, certain vitamins and dietary compounds have been shown to exert physiological effects on immune cells that can result in the increased expression of various receptors, including IL-5R. Vitamin D3, for instance, may enhance IL-5R expression through its interaction with nuclear vitamin D receptors, which can influence gene expression. Similarly, retinoic acid, a metabolite of vitamin A, may also play a role in the differentiation of immune cells, leading to the upregulation of IL-5R. Other activators include small molecular compounds that interact with intracellular signaling pathways. These compounds may stimulate transcription factors or inhibit enzymes, resulting in the expression of a range of proteins, including IL-5R. The intricate interplay of these activators with the immune system's regulatory network underscores the complexity of immune responses and the fine-tuning required for their regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate may upregulate IL-5R by inhibiting dihydrofolate reductase, leading to a compensatory increase in certain cytokine expressions that could include IL-5R as part of a complex immune response. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol could stimulate IL-5R expression by binding to vitamin D receptors which interact with specific promoter regions of genes involved in immune cell differentiation where IL-5R is expressed. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid may induce IL-5R expression through its role as an active metabolite of vitamin A, influencing the maturation and differentiation of immune cells, which could include upregulation of IL-5R on eosinophils. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Thalidomide is known to stimulate T-cell responses and could indirectly stimulate the upregulation of IL-5R by increasing the secretion of IL-5 from T-cells, which in turn promotes IL-5R expression on target cells. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone might upregulate IL-5R by reducing pro-inflammatory cytokines, which may cause a homeostatic increase in IL-5 production as a feedback mechanism, thereby enhancing IL-5R expression on responsive cells. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin could induce the expression of IL-5R by inhibiting cyclooxygenase enzymes and modifying the synthesis of prostaglandins, leading to altered cytokine production dynamics that may include IL-5R upregulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to stimulate antioxidant response elements in cellular DNA, which could lead to the upregulation of various protective genes, potentially including genes that increase IL-5R expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may induce IL-5R by activating sirtuin pathways that are involved in the regulation of longevity and inflammation, potentially leading to an increase in IL-5R expression as part of an anti-inflammatory response. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is known to stimulate the expression of genes involved in the immune defense, which may include genes responsible for the upregulation of IL-5R on certain immune cells. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane could increase IL-5R expression through its activation of Nrf2, a transcription factor that induces the expression of a variety of genes involved in cellular defense mechanisms, potentially including IL-5R. | ||||||