Resveratrol CAS: 501-36-0
MF: C14H12O3
MW: 228.24
A natural phenolic antioxidant that is a potent activator of SIRT1 and inhibitor of Cox-1.

Resveratrol (CAS 501-36-0)

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Synonym: Trans-3,4′,5-Trihydroxystilbene; 1,3-Benzenediol, 5-[2-(4-hydroxyphenyl)ethenyl]-
Application A natural phenolic antioxidant that is a potent activator of SIRT1 and inhibitor of Cox-1
CAS 등록번호: 501-36-0
순도: ≥98%
분자량: 228.24
분자식: C14H12O3
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a natural polyphenol derived from red wine; in Asian folk-medicine it and it′s glycoside, polydatin (sc-203203) are the primary ingredients of Kojo-Kon (derived from the dried root of Japanese knotweed). This trihydroxystilbene is derived from various sources and has been studied with regard to numerous applications including reducing serum lipids, inhibition of platelet aggregation, and actions as a chemopreventative agent and antioxidant. Resveratrol has been shown to increase the longevity of yeast and to display antiproliferative effects on cancer stem cells in vitro. Resveratrol is a specific inhibitor of Cox-1 (cyclooxygenase-1) via inhibition of the hydroperoxidase activity of Cox-1.

Resveratrol has also been used extensively in stem cell studies to enhance self-renewal and multipotency of mesencymal stem cells (MSC′s) in vitro. Numerous studies have been conducted with regard to resveratrol-modified cardiac stem cells enhancing cardiac healing in vitro. Similar studies with bone marrow derived stem cells (BMSCs) have shown that resveratrol acts as a NF-κB inhibitor to protect MSC-derived chondrocytes in vitro. Additional research with resveratrol used to treat adipose-derived mesenchymal stem cells (ADMSCs) resulted in increased alkaline phosphatase activity and osteocalcin levels; thus enriching the MSC and osteoprogenitor cell populations in cultured ADMSCs in vitro.


References

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12. Pandey, P.R., et al. 2010. Breast Cancer Res Treat. PMID: 21188630
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Appearance :
Powder
Physical State :
Solid
용해도 :
Soluble in water (3 mg/100mL), ethanol (50 mg/mL), DMSO (≥16 mg/mL), DMF (~65 mg/mL), PBS (pH 7.2) (~100µg/mL), methanol, and acetone (50 mg/mL).
저장 :
Store at -20° C
녹는점 :
253-255° C
비등점 :
449.12° C at 760 mmHg (Predicted)
밀도 :
1.36 g/cm3 (Predicted)
굴절률 :
n20D 1.76 (Predicted)
IC50 :
cytochrome P450 1A1: IC50 = 23 µM; PKD in vitro: IC50 = 200 µM; PKD in vivo: IC50 = 800 µM; Cytochrome P450 2C19: IC50 = 3 µM (human); HL-60 (Promyeloblast leukemia cells): IC50 = 36.3 µM (human); Cyclooxygenase-1: IC50 = 535 nM (Ovis aries); Monoamine oxidase A: IC50 = 449 nM (human)
pK Values :
pKa: 9.22 (Predicted)
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
RTECS :
CZ8987000
PubChem CID :
5056
Merck Index :
14: 8158
MDL Number :
MFCD00133799
EC Number :
610-504-8
Beilstein Registry :
1912434
SMILES :
C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O

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Resveratrol  논문정보

다른 사용자의 Resveratrol사용법보기. 클릭하여 PubMed entry보기 .

Citations 1 to 10 of {3} total

PMID: # 31040579  Al-Tamimi, H.|Al-Dawood, A.|Awaishesh, S.|Abdalla, T.| et al. 2019. Vet World. 12: 337-344.

PMID: # 29906565  Nøhr-Meldgaard, K. et al. 2018. Int. J. Antimicrob. Agents. 52: 390-396.

PMID: # 29958542  Furat Rencber, S.|Kurnaz Ozbek, S.|Eraldemır, C.|Sezer, Z.|Kum, T.|Ceylan, S.|Guzel, E.| et al. 2018. J Ovarian Res. 11: 55.

PMID: # 28750181  2018. Connect. Tissue Res. 59: 245-254.

PMID: # 27771282  Kaur, M. et al. 2017. Brain Res. 1654: 9-23.

PMID: # 28603085  Fernández-Del-Río, L. et al. 2017. Free Radic. Biol. Med. 110: 176-187.

PMID: # 28915620  Islam, SU. et al. 2017. Oncotarget. 8: 56659-56671.

PMID: # 27129153  Labay, E. et al. 2016. Oncotarget.

PMID: # 26870238  Xiong, W. et al. 2016. Oncol Lett. 11: 484-490.

PMID: # 27634755  Allain, C. et al. 2016. Cancer Res. 76: 6374-6381.

Citations 1 to 10 of {3} total
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