IL-34 Activators
The group of chemicals that influence the activation of IL-34, are involved in complex cellular signaling pathways including the MAPK, PI3K/AKT/mTOR, and the NF-κB pathways. These chemicals either activate or inhibit specific components of these pathways, leading to an increase in IL-34 expression.Phorbol 12-myristate 13-acetate (PMA) is a potent activator of protein kinase C (PKC), which in turn activates the MAPK pathway. ERK1/2 phosphorylation, a key event in the MAPK pathway, stimulates the expression of IL-34. LY294002 and Wortmannin both inhibit PI3K, leading to a decrease in AKT phosphorylation and modulation of mTOR signaling. As mTOR inhibition has been shown to upregulate IL-34, these PI3K inhibitors can increase IL-34 expression. Rapamycin is a direct mTOR inhibitor, and through mTOR inhibition, Rapamycin can result in increased IL-34 expression.
SP600125, SB203580, U0126, and PD98059 are all inhibitors of different components of the MAPK pathway, specifically JNK, p38, and MEK respectively. As the activation of these components normally suppresses IL-34 expression, their inhibition can lead to increased IL-34 levels. BAY 11-7082 and Parthenolide both inhibit the NF-κB pathway, which also normally suppresses IL-34. By inhibiting NF-κB, these chemicals can lead to increased IL-34 expression. Curcumin can inhibit both the MAPK and NF-κB pathways, thus leading to increased IL-34 expression. Resveratrol modulates SIRT1, a pathway that intersects with NF-κB signaling. By activating SIRT1, Resveratrol can influence NF-κB activity and subsequently IL-34 expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). By activating PKC, PMA influences the downstream signaling pathways, including MAPK pathway. Phosphorylation of ERK1/2, a key event in the MAPK pathway, is known to stimulate the expression of IL-34. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of PI3K. The suppression of PI3K leads to a decrease in AKT phosphorylation, which can influence mTOR signaling. This can increase the expression of IL-34, as mTOR inhibition has been shown to upregulate IL-34. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is a potent inhibitor of mTOR, a central cell growth regulator. Inhibition of mTOR can lead to increased expression of IL-34. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another potent PI3K inhibitor. Similar to LY294002, Wortmannin's inhibition of PI3K can lead to increased IL-34 expression through modulation of the mTOR pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective JNK inhibitor that can inhibit the MAPK pathway. Since JNK activation normally suppresses IL-34 expression, SP600125 can indirectly increase IL-34 levels by inhibiting JNK. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a selective p38 MAPK inhibitor. Inhibition of p38 can lead to increased IL-34 expression, as p38 MAPK activity normally suppresses IL-34. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is another MEK inhibitor. Similar to U0126, PD98059's inhibition of MEK can lead to increased IL-34 expression. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 irreversibly inhibits IκBα phosphorylation, thereby inhibiting the NF-κB pathway. Inhibition of NF-κB can lead to increased IL-34 expression, since NF-κB activity normally suppresses IL-34. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide inhibits NF-κB by preventing IκB degradation. Similar to BAY 11-7082, Parthenolide's inhibition of NF-κB can lead to increased IL-34 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can inhibit both the MAPK and NF-κB pathways. Through this dual inhibition, Curcumin can lead to an increase in IL-34 expression. | ||||||