IL-34 Inhibitors
The inhibitors listed above primarily target the colony-stimulating factor-1 receptor (CSF-1R), which is a key receptor for IL-34. By modulating CSF-1R activity, these compounds can indirectly influence IL-34-mediated signaling pathways, particularly those involved in immune regulation and myeloid cell development. Pexidartinib, BLZ945, GW2580, JNJ-40346527, and PLX647 are small-molecule inhibitors that specifically target CSF-1R, thereby potentially modulating IL-34's effects mediated through this receptor.
Monoclonal antibodies such as Cabiralizumab and Emactuzumab target CSF-1R, which can alter the biological activities of IL-34 by inhibiting its primary receptor. Masitinib, Sorafenib, Sunitinib, Imatinib, and Dasatinib are tyrosine kinase inhibitors with broader targets, including CSF-1R. Their effects on CSF-1R can indirectly influence IL-34's role in various biological processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
cFMS Receptor Tyrosine Kinase Inhibitor | 870483-87-7 | sc-203877 sc-203877A | 1 mg 5 mg | $32.00 $54.00 | ||
GW2580 is a small-molecule inhibitor of CSF-1R, which could indirectly modulate IL-34's biological activities. | ||||||
Masitinib | 790299-79-5 | sc-211777 | 10 mg | $184.00 | ||
Masitinib is a tyrosine kinase inhibitor that targets CSF-1R, among others, and may affect IL-34 mediated pathways. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Sorafenib, a multi-kinase inhibitor, can inhibit CSF-1R and may indirectly impact IL-34's biological activities. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $153.00 $938.00 | 5 | |
Sunitinib, another multi-kinase inhibitor, targets CSF-1R and could influence IL-34 signaling. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $26.00 $119.00 $213.00 | 27 | |
Imatinib, known for its BCR-ABL inhibition, also targets CSF-1R and might affect IL-34 related pathways. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a broad-spectrum kinase inhibitor that includes CSF-1R, potentially impacting IL-34 signaling. | ||||||