Molecular structure of cFMS Receptor Tyrosine Kinase Inhibitor, CAS Number: 870483-87-7
cFMS Receptor Tyrosine Kinase Inhibitor (CAS 870483-87-7)
Alternate Names:
5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)-pyrimidine-2,4-diamine; CSF-1 Receptor Inhibitor; GW2580
Application:
cFMS Receptor Tyrosine Kinase Inhibitor is a cFMS kinase activity inhibitor
CAS Number:
870483-87-7
Purity:
≥97%
Molecular Weight:
366.4
Molecular Formula:
C20H22N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
cFMS Receptor Tyrosine Kinase Inhibitor is a selective cell-permeable diaminopyrimidine compound that inhibits colony-stimulating factor (CSF)-1 resulting in suppression of monocyte growth and bone degradation in vitro and inhibits CSF-1 signaling through cFMS kinase. In addition, studies show that cFMS Receptor Tyrosine Kinase Inhibitor inhibits nuclear factor B ligand, a molecule responsible for osteoclast differentiation. Further studies confirmed that the inhibitor partially inhibits thioglycolate-induced cell influx into the peritoneal cavity and completely suppresses the growth of CSF-1-dependent tumor cells and M-NFS-60 myeloid cells.
cFMS Receptor Tyrosine Kinase Inhibitor (CAS 870483-87-7) References
- Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. | Conway, JG., et al. 2005. Proc Natl Acad Sci U S A. 102: 16078-83. PMID: 16249345
- Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats. | Conway, JG., et al. 2008. J Pharmacol Exp Ther. 326: 41-50. PMID: 18434589
- Role of cell cycle-associated proteins in microglial proliferation in the axotomized rat facial nucleus. | Yamamoto, S., et al. 2012. Glia. 60: 570-81. PMID: 22258892
- Kinase Inhibitors with Antiepileptic Properties Identified with a Novel in Vitro Screening Platform. | Liu, J., et al. 2019. Int J Mol Sci. 20: PMID: 31117204
- Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration. | Neal, ML., et al. 2020. FASEB J. 34: 1679-1694. PMID: 31914683
- Mechanisms of Microglia Proliferation in a Rat Model of Facial Nerve Anatomy. | Ishijima, T. and Nakajima, K. 2023. Biology (Basel). 12: PMID: 37627005
- CSF-1 and Notch signaling cooperate in macrophage instruction and tissue repair during peripheral limb ischemia. | Kapanadze, T., et al. 2023. Front Immunol. 14: 1240327. PMID: 37691936
Inhibitor of:
ARHGEF18, BMP-3, c-Fms-CSF-1R, CD200R4, EMR1 F4/80, FNDC8, IDE, IGFL1, IL-34, M-CSF, MMD, PDGF-D, PKDCC, RGD1562043, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cFMS Receptor Tyrosine Kinase Inhibitor, 1 mg | sc-203877 | 1 mg | $31.00 | |||
cFMS Receptor Tyrosine Kinase Inhibitor, 5 mg | sc-203877A | 5 mg | $53.00 |