IL-32 Inhibitors
IL-32 inhibitors are a class of chemical compounds designed to specifically target and inhibit the activity of Interleukin-32 (IL-32), a proinflammatory cytokine that plays a significant role in the immune response and inflammatory processes within the body. These inhibitors are developed as research tools to better understand the intricate mechanisms of immune regulation and inflammation. Interleukin-32 itself is a multifaceted cytokine, with various isoforms and functions, and its dysregulation. IL-32 inhibitors aim to modulate the expression and activity of IL-32, potentially leading to insights into the development of novel interventions in the future.
The chemical structure and properties of IL-32 inhibitors can vary, but their common characteristic is the ability to interfere with the signaling pathways associated with IL-32. This inhibition may occur through various mechanisms, such as binding to IL-32 receptors or the production of IL-32 itself. By targeting IL-32, researchers hope to gain a deeper understanding of its role in inflammatory diseases and its interactions with other immune molecules.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide is a sesquiterpene lactone derived from the feverfew plant. It inhibits NF-κB, a transcription factor that can regulate IL-32 expression. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $210.00 $252.00 $1740.00 $1964.00 | 34 | |
JSH-23 is a small molecule that inhibits the nuclear translocation of NF-κB, potentially reducing IL-32 expression. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a steroidal metabolite of fungi which acts as a potent PI3K inhibitor, affecting several cytokines including IL-32 through the PI3K/Akt signaling pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a pyridinyl imidazole compound that selectively inhibits p38 MAPK, influencing the production and function of IL-32. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a synthetic compound that inhibits MEK1 activation and can affect MAPK/ERK pathways, which are involved in IL-32 regulation. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 is an irreversible inhibitor of NF-κB, impacting the transcription of IL-32. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a peptide aldehyde that inhibits proteasome and NF-κB activity, potentially reducing the levels of IL-32. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an anthrapyrazolone inhibitor that selectively inhibits c-Jun N-terminal kinase (JNK), which can influence IL-32 expression. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $32.00 $63.00 | 11 | |
PDTC is a thiol compound that inhibits NF-κB activation, affecting the production of IL-32. | ||||||
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $74.00 | 256 | |
SN50 is a cell-permeable peptide that can inhibit the nuclear translocation of NF-κB, thereby potentially reducing IL-32 expression. | ||||||