IL-1F8 Activators
The activation of IL-1F8, a member of the interleukin-1 family, is closely linked with the modulation of the NF-κB and MAPK signaling pathways. Chemicals such as Resveratrol, Quercetin, Parthenolide, and BAY 11-7082, among others, can have a bearing on the NF-κB pathway. Resveratrol, a natural phenol, activates the sirtuin 1 (SIRT1) pathway, thereby indirectly influencing the activation of NF-κB and subsequently IL-1F8. Quercetin, a flavonoid, inhibits the PI3K/Akt pathway, an upstream regulator of the NF-κB pathway, and in doing so, it can modulate the activation of IL-1F8MAPK pathway, another signaling route involved in IL-1F8 modulation, can be influenced by chemicals such as PD98059, U0126, SP600125, SB203580, and Curcumin. PD98059 and U0126, both MEK inhibitors, can inhibit the MAPK pathway, affecting the subsequent activation of IL-1F8. SP600125, a selective JNK inhibitor, and SB203580, a selective p38 MAPK inhibitor, also inhibit the MAPK pathway, thereby having an effect on IL-1F8 activation.
Chemicals like Curcumin, Sulforaphane, Capsaicin, and EGCG can influence both the NF-κB and MAPK pathways or the NF-κB pathway alone. Curcumin, a natural phenol, can inhibit both the MAPK and NF-κB pathways, thus having a dual effect on IL-1F8 activation. Sulforaphane, an isothiocyanate, and EGCG, a type of catechin, inhibit the NF-κB pathway, thereby modulating IL-1F8 activation. Capsaicin, an alkaloid, activates the TRPV1 receptor, leading to a cascade of events resulting in the activation of the NF-κB pathway and subsequent IL-1F8 activation. In conclusion, while these chemicals are not direct activators of IL-1F8, their influence on the NF-κB and MAPK pathways can indirectly modulate the activation of IL-1F8.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a natural phenol that can activate the sirtuin 1 (SIRT1) pathway. SIRT1 is known to inhibit NF-κB signaling, so resveratrol, by activating SIRT1, can modulate NF-κB pathway and thus influence the activation of IL-1F8. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that inhibits the PI3K/Akt pathway, which is upstream of the NF-κB pathway. By inhibiting PI3K/Akt, quercetin can modulate the activation of NF-κB and subsequently IL-1F8. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide is a sesquiterpene lactone that inhibits the activation of NF-κB by preventing the degradation of its inhibitor, IκB. This action can indirectly influence the activation of IL-1F8. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 irreversibly inhibits the TNF-α-induced phosphorylation of IκBα, thereby inhibiting the NF-κB pathway. This inhibition may impact the activation of IL-1F8. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective MEK inhibitor that can inhibit the MAPK pathway. By inhibiting MEK, PD98059 can modulate the activation of the MAPK pathway and subsequently IL-1F8. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective JNK inhibitor that can inhibit the MAPK pathway. By inhibiting JNK, SP600125 can modulate the activation of the MAPK pathway and subsequently IL-1F8. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a selective p38 MAPK inhibitor that can inhibit the MAPK pathway. By inhibiting p38, SB203580 can modulate the activation of the MAPK pathway and subsequently IL-1F8. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a natural phenol that can inhibit both the MAPK and NF-κB pathways. Through this dual inhibition, curcumin can indirectly influence the activation of IL-1F8. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is an isothiocyanate that can inhibit the NF-κB pathway. By inhibiting NF-κB, sulforaphane can modulate the activation of IL-1F8. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin is an alkaloid that can activate the TRPV1 receptor, leading to Ca2+ influx and subsequent activation of the NF-κB pathway. This action can indirectly influence the activation of IL-1F8. | ||||||