IL-11Rα Inhibitors
The chemical class of IL-11Rα Inhibitors includes a diverse array of specific compounds that can influence the signaling pathways crucial for IL-11Rα activity. Ruxolitinib and Stattic, targeting JAK and STAT3 pathways, respectively, potentially inhibit signaling processes crucial for IL-11Rα-mediated responses. BAY 11-7082, an NF-kappaB inhibitor, and SB431542, a TGF-beta signaling inhibitor, can modulate broader inflammatory and proliferative pathways that might intersect with IL-11Rα signaling.
LY294002 and Everolimus, inhibitors of the PI3K/AKT and mTOR pathways, respectively, can affect cell proliferation and immune response pathways, potentially influencing IL-11Rα activity. Prednisone, a glucocorticoid, might modulate immune responses and downregulate IL-11Rα in certain contexts. Trichostatin A, an HDAC inhibitor, and Imatinib, a tyrosine kinase inhibitor, can alter cell signaling and gene expression, potentially leading to reduced IL-11Rα activity. Cyclosporine A and Bortezomib are also included for their roles in modulating immune signaling and proteasome function, respectively, which could indirectly impact IL-11Rα.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
A JAK inhibitor that disrupts the JAK-STAT signaling pathway, potentially leading to the inhibition of IL-11Rα signaling. | ||||||
Stat3 inhibitor V, stattic | 19983-44-9 | sc-202818 sc-202818A sc-202818B sc-202818C sc-202818D sc-202818E sc-202818F | 25 mg 100 mg 250 mg 500 mg 1 g 2.5 g 5 g | $130.00 $196.00 $274.00 $512.00 $731.00 $1408.00 $2091.00 | 114 | |
A STAT3 inhibitor that can disrupt downstream signaling of cytokine receptors, potentially inhibiting IL-11Rα-mediated pathways. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
An NF-kappaB inhibitor that can suppress inflammatory signaling pathways, potentially reducing the activity of receptors like IL-11Rα. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
A TGF-beta signaling inhibitor that might indirectly affect IL-11Rα, as TGF-beta is involved in various overlapping signaling pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K/AKT pathway inhibitor that can affect various cellular signaling pathways, potentially including those associated with IL-11Rα. | ||||||
Prednisone | 53-03-2 | sc-205816 sc-205816A sc-205816B | 1 g 5 g 25 g | $42.00 $136.00 $676.00 | 2 | |
A glucocorticoid that can modulate immune responses and might downregulate IL-11Rα expression in certain contexts. | ||||||
Everolimus | 159351-69-6 | sc-218452 sc-218452A | 5 mg 50 mg | $131.00 $651.00 | 7 | |
An mTOR inhibitor that affects cell proliferation and survival pathways, potentially influencing IL-11Rα activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A MAPK inhibitor that disrupts signaling pathways involved in cell proliferation and inflammation, potentially affecting IL-11Rα signaling. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
An HDAC inhibitor that changes gene expression patterns, potentially leading to the downregulation of IL-11Rα. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $26.00 $119.00 $213.00 | 27 | |
A tyrosine kinase inhibitor that disrupts various signaling pathways, potentially including those involving IL-11Rα. | ||||||