IFIX Inhibitors
IFIX Inhibitors encompass a variety of chemical compounds that indirectly impede the functional activity of IFIX, predominantly by targeting the NF-κB pathway, which is crucial for the transcriptional regulation of IFIX. Pyrrolidinedithiocarbamic acid and 4-Methyl-N1-(3-phenylpropyl)benzene-1,2-diamine are both inhibitors that obstruct the nuclear translocation of NF-κB, thus preventing it from activating genes including IFIX. Similarly, SN50, with its peptide-based mechanism, inhibits the nuclear localization sequence of NF-κB, resulting in diminished expression of IFIX. IKK-2 Inhibitor IV and BAY 11-7082, which prevents the phosphorylation of IκBα, both act upstream in the NF-κB pathway to inhibit the transcriptional activity of IFIX indirectly. Parthenolide, by obstructing NF-κB DNA binding, and MG-132, a proteasome inhibitor that stalls IκBα degradationand in turn NF-κB activation, both result in reduced IFIX activity due to decreased gene expression. Quinacrine and Sulforaphane also target NF-κB's DNA-binding and activation, respectively, leading to a reduction in IFIX functional activity by limiting its transcriptional induction.
In addition to these inhibitors, Andrographolide and Celastrol both act on components of NF-κB signaling; Andrographolide covalently modifies the p50 subunit, and Celastrol promotes the degradation of IκB kinase, each leading to a decrease in IFIX expression. Epigallocatechin gallate, a well-known green tea polyphenol, similarly inhibits the degradation of IκBα, suppressing NF-κB activation and subsequently diminishing the activity of IFIX. Collectively, these IFIX inhibitors leverage the NF-κB pathway to indirectly suppress the functional activity of IFIX by reducing its expression at the transcriptional level, delineating a critical interplay between NF-κB signaling and the regulation of IFIX.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $32.00 $63.00 | 11 | |
Pyrrolidinedithiocarbamic acid is a nuclear factor kappa B (NF-κB) inhibitor that prevents the translocation of NF-κB into the nucleus. Since IFIX is a transcription factor that can be regulated by NF-κB, inhibition of NF-κB by Pyrrolidinedithiocarbamic acid would likely result in a decrease in IFIX expression and its functional activity. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $210.00 $252.00 $1740.00 $1964.00 | 34 | |
4-Methyl-N1-(3-phenylpropyl)benzene-1,2-diamine is another inhibitor of NF-κB that specifically blocks the nuclear translocation of the NF-κB p65 subunit. By inhibiting NF-κB, JSH-23 can indirectly diminish the functional activity of IFIX by reducing its expression at the transcriptional level. | ||||||
IKK-2 Inhibitor IV | 507475-17-4 | sc-203083 | 500 µg | $130.00 | 12 | |
IKK-2 Inhibitor IV that prevents the activation of NF-κB by inhibiting IκB kinase. By blocking this upstream kinase, TPCA-1 indirectly diminishes the functional activity of IFIX by reducing its transcriptional activation. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 inhibits NF-κB by preventing the phosphorylation of IκBα, which is necessary for the activation and nuclear translocation of NF-κB. This indirect inhibition can lead to decreased expression and activity of IFIX. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide inhibits NF-κB by blocking the DNA binding of the NF-κB complex. As a result, it can diminish the expression of downstream genes like IFIX, thereby inhibiting its activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor that can prevent the degradation of IκBα, leading to inhibition of NF-κB activation. This action can result in reduced transcriptional activation of IFIX, diminishing its activity. | ||||||
Quinacrine, Dihydrochloride | 69-05-6 | sc-204222 sc-204222B sc-204222A sc-204222C sc-204222D | 100 mg 1 g 5 g 200 g 300 g | $45.00 $56.00 $85.00 $3193.00 $4726.00 | 4 | |
Quinacrine inhibits NF-κB by blocking its DNA-binding activity. The inhibition of NF-κB can indirectly decrease the expression and functional activity of IFIX. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane inhibits NF-κB by inducing the expression of antioxidant response elements and by inhibiting the phosphorylation and degradation of IκBα. This leads to a decrease in NF-κB activation and a subsequent reduction in IFIX activity. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $39.00 | 7 | |
Andrographolide inhibits NF-κB activation by covalently modifying the p50 subunit. This inhibition can result in decreased IFIX expression and activity due to reduced transcriptional activation by NF-κB. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $155.00 | 6 | |
Celastrol is a triterpenoid that inhibits NF-κB signaling by promoting the degradation of IκB kinase, which is necessary for NF-κB activation. This can lead to diminished IFIX expression and activity. | ||||||