I-SceI Inhibitors
Chemical Class Description: The class of I-SceI inhibitors consists of compounds that indirectly modulate the activity of I-SceI by affecting the DNA substrate with which it interacts. These compounds, while not directly interacting with I-SceI, influence DNA structure, replication, and repair mechanisms, crucial for I-SceI's role in DNA cleavage. DNA intercalating agents like Ethidium Bromide, Doxorubicin, Daunorubicin, Actinomycin D, and Chloroquine can alter the DNA conformation, thereby potentially hindering the ability of I-SceI to recognize and cleave its specific DNA site. DNA alkylating agents such as Mitomycin C and Cisplatin form adducts with DNA, which might interfere with the DNA recognition and cleavage by I-SceI.
Topoisomerase inhibitors like Camptothecin and Etoposide affect the topology of DNA, which could influence I-SceI activity. Aphidicolin, by inhibiting DNA polymerase, impacts DNA replication, potentially affecting the structure and availability of DNA for I-SceI action. Hydroxyurea and Bleomycin, through their effects on ribonucleotide reductase inhibition and DNA strand breakage, respectively, represent additional mechanisms that could indirectly impact the function of I-SceI.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethidium bromide | 1239-45-8 | sc-203735 sc-203735A sc-203735B sc-203735C | 1 g 5 g 25 g 100 g | $47.00 $147.00 $576.00 $2045.00 | 12 | |
Intercalates into DNA, potentially altering the DNA structure and hindering I-SceI binding. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Alkylates DNA, possibly affecting DNA cleavage by I-SceI. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Forms DNA adducts, which could interfere with I-SceI DNA recognition and cleavage. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Interacts with DNA by intercalation, potentially disrupting I-SceI's access to its recognition site. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Inhibits DNA topoisomerase I, potentially affecting the DNA conformation and I-SceI activity. | ||||||
Daunorubicin hydrochloride | 23541-50-6 | sc-200921 sc-200921A sc-200921B sc-200921C | 10 mg 50 mg 250 mg 1 g | $103.00 $429.00 $821.00 $1538.00 | 4 | |
Similar to Doxorubicin, intercalates into DNA, potentially hindering I-SceI activity. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Inhibits topoisomerase II, potentially affecting DNA topology and I-SceI function. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Inhibits DNA polymerase, potentially affecting DNA replication and structure relevant to I-SceI activity. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Binds to DNA and inhibits transcription, possibly affecting I-SceI DNA interaction. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Inhibits ribonucleotide reductase, affecting DNA synthesis and potentially the DNA structure for I-SceI action. | ||||||