HYI Activators
HYI Activators are a class of compounds that influence various signaling pathways and cellular processes to enhance the activity of HYI. Forskolin, through the activation of adenylate cyclase, increases cAMP levels, which in turn, through PKA activation, can enhance the phosphorylation status of proteins involved in HYI's pathway, including HYI itself. Similarly, PMA, through the activation of PKC, can phosphorylate target proteins, which may include those within the HYI signaling cascade, thereby enhancing HYI's functional activity.
Compounds like IBMX, which prevent the degradation of cAMP, and Sildenafil, an inhibitor of phosphodiesterase 5, raise the levels of cyclic nucleotides (cAMP and cGMP respectively),leading to the activation of their respective protein kinases (PKA and PKG). This activation cascade can result in phosphorylation events that enhance HYI activity. Epigallocatechin gallate (EGCG) can affect DNA methylation patterns, leading to increased HYI expression by making the HYI gene more accessible for transcription. Spermidine, by promoting autophagy, might facilitate the removal of negative regulators of HYI, leading to its indirect activation. Curcumin and resveratrol both act on signaling pathways that can influence the activity of HYI. Curcumin's inhibition of NF-κB may reduce the expression of proteins that negatively regulate HYI, while resveratrol's activation of SIRT1 might lead to deacetylation of proteins within the HYI pathway, enhancing HYI's activity. Lithium chloride and metformin, through the inhibition of GSK-3β and activation of AMPK respectively, can indirectly influence HYI's activity by modifying the activity of proteins that interact with HYI. Sodium butyrate influences gene expression by changing the chromatin structure, increasing the expression of genes within the HYI pathway. Lastly, capsaicin's activation of TRPV1 and subsequent calcium signaling can indirectly enhance HYI activity through the activation of calcium-dependent proteins that interact with HYI.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased levels of cAMP, which can enhance PKA activity. PKA then phosphorylates various proteins, potentially increasing the activity of HYI by phosphorylation on serine/threonine residues. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate target proteins, altering their activity. PKC-mediated phosphorylation of proteins in the HYI pathway could enhance HYI functional activity through post-translational modifications. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, leading to an increase in cAMP levels by preventing its breakdown. Elevated cAMP can enhance the PKA signaling cascade, potentially increasing HYI activity through downstream effects. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to inhibit certain types of DNA methyltransferases, which could lead to hypomethylation of the HYI promoter region and enhance HYI activity through increased accessibility of the DNA for transcriptional machinery. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine is a polyamine that is involved in cellular processes such as DNA stabilization. It can enhance autophagy, which might lead to the degradation of negative regulators of HYI, thereby indirectly increasing HYI activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit NF-κB signaling, which might lead to the reduced expression of proteins that negatively regulate HYI, resulting in the increased functional activity of HYI. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, an NAD-dependent deacetylase, which can deacetylate proteins and affect their activity. Activation of SIRT1 by resveratrol could lead to deacetylation of components in the HYI pathway, enhancing HYI activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3β, which can lead to the activation of Wnt signaling. While Wnt is not directly related to HYI, the inhibition of GSK-3β might release proteins that can enhance the activity of HYI through stabilization and activation. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
Metformin activates AMPK, which can enhance cellular energy status. Through the activation of AMPK, the energy-sensing pathway might indirectly increase HYI activity by phosphorylating and activating proteins that interact with HYI. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that can increase acetylation levels on histones, leading to an open chromatin structure. This could enhance the transcriptional activity of genes associated with the HYI pathway. | ||||||