HuC Activators
HuC activators are a specific category of chemical agents that target and modulate the activity of HuC, a member of the ELAV-like family of RNA-binding proteins. HuC, also known as ELAVL3, is predominantly expressed in the nervous system and plays a crucial role in neuronal development and function. It is involved in various aspects of RNA metabolism, including RNA stabilization, alternative splicing, and translation regulation, which are essential for proper gene expression and neuronal differentiation.
The mechanism by which HuC activators function can be direct or indirect. Direct activators interact with HuC at specific domains to enhance its RNA-binding capacity or stabilize its interaction with target mRNAs. This could lead to increased stability and translation of mRNAs that are critical for neuronal maintenance and plasticity. By influencing the RNA-binding affinity or specificity of HuC, such activators could adjust the subset of mRNAs that are regulated by HuC, thereby altering the proteomic landscape of the neuron. Indirect activators may affect HuC activity by altering its expression levels or by modulating cellular pathways that influence its post-translational modifications. These modifications, such as phosphorylation or ubiquitination, can impact HuC's localization, stability, or interaction with other proteins and mRNAs. Indirect activators could also operate by influencing signaling pathways that affect the overall environment in which HuC operates, thereby modulating its function in a broader context.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylate cyclase, enhancing cAMP levels. Elevated cAMP can stimulate protein kinase A (PKA), which phosphorylates and activates many downstream targets. HuC, being a RNA-binding protein, can be post-translationally modified and activated by such phosphorylation events. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic receptor agonist. The activation of these receptors increases cAMP levels, stimulating PKA. The activation of PKA can lead to the phosphorylation and subsequent activation of HuC. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase 4 (PDE4), leading to increased cAMP levels. The elevated cAMP triggers PKA, which can phosphorylate and activate HuC. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX non-selectively inhibits phosphodiesterases, causing an increase in cAMP levels. The accumulation of cAMP triggers PKA, which can phosphorylate HuC leading to its activation. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine activates beta-adrenergic receptors. This receptor activation increases cAMP levels, which can stimulate PKA. The activated PKA can phosphorylate HuC, leading to its activation. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $320.00 $475.00 | 3 | |
Norepinephrine activates beta-adrenergic receptors, leading to increased cAMP levels. These levels stimulate PKA, which can phosphorylate and activate HuC. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 is a prostaglandin that stimulates adenylate cyclase to increase cAMP levels. The resulting cAMP accumulation triggers PKA, which can phosphorylate and activate HuC. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $93.00 $356.00 | 13 | |
SQ 22536 is an adenylate cyclase inhibitor. The reduction of cAMP levels and subsequent decrease in PKA activity can paradoxically lead to the activation of HuC due to the complex feedback mechanisms in the signaling pathway. | ||||||
Papaverine | 58-74-2 | sc-279951 sc-279951A sc-279951B | 10 mg 50 mg 100 mg | $153.00 $265.00 $459.00 | ||
Papaverine, a PDE inhibitor, raises cellular cAMP levels. The increased cAMP triggers PKA, which can phosphorylate and activate HuC. | ||||||
Dobutamine | 34368-04-2 | sc-507555 | 100 mg | $295.00 | ||
Dobutamine is a beta-1 adrenergic receptor agonist that increases cAMP levels, which in turn stimulates PKA. PKA can phosphorylate HuC leading to its activation. | ||||||