HtrA3 Activators
HtrA3, a serine protease of the HtrA family, plays a significant role in cellular homeostasis and stress response. It shares structural and functional similarities with its prokaryotic counterparts but has evolved distinct roles in mammalian systems, including involvement in protein quality control and signaling pathways that respond to intra- and extracellular changes. The expression of HtrA3 can be influenced by a variety of stress-related stimuli, reflecting its integral part in maintaining cellular integrity. HtrA3 is differentially expressed in various tissues and has been studied extensively for its role in cellular proliferation, apoptosis, and the regulation of extracellular matrix components. The protein's activity can be modulated at multiple levels, ranging from transcriptional control to post-translational modifications, which allows for a finely tuned response to cellular stressors.
Chemical compounds that can induce the expression of HtrA3 include a diverse set of molecules known to engage with cellular stress pathways. For instance, compounds that lead to oxidative stress, such as hydrogen peroxide, can enhance the expression of genes that are pivotal in the cellular defense mechanism, including HtrA3. Similarly, molecules that disrupt normal cellular homeostasis, like tunicamycin, which causes endoplasmic reticulum stress, may also induce the expression of HtrA3 as part of the unfolded protein response. Furthermore, agents that alter gene expression through epigenetic modifications, such as 5-Azacytidine and Trichostatin A, can result in increased transcription of a wide array of genes, potentially including those encoding for HtrA3. These activators point to the complex network of regulatory mechanisms that govern the expression of HtrA3, highlighting the protein's role in cellular adaptability and maintenance of functional equilibrium under varying conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid may initiate transcriptional activation of genes by binding to retinoic acid receptors, which could upregulate serine protease genes such as HtrA3 as part of cellular differentiation processes. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferase, 5-Azacytidine reduces DNA methylation, which can result in the reactivation of silenced genes, potentially stimulating the transcription of HtrA3. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, as a histone deacetylase inhibitor, can enhance acetylation of histones, leading to a more relaxed chromatin structure and a consequent increase in gene transcription, including possibly the gene encoding HtrA3. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane activates the transcription factor Nrf2, leading to the enhanced expression of antioxidant response genes, which may include the gene encoding HtrA3 as a response to oxidative stress. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may exert a stimulatory effect on the transcription of genes involved in the cellular stress response by activating various transcription factors and signaling pathways, which could include upregulation of HtrA3 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to stimulate sirtuins and may promote the transcription of genes involved in cellular stress resistance, potentially including those related to the serine protease HtrA3. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide, by imposing oxidative stress, can activate signaling pathways that lead to the transcriptional activation of genes encoding protective proteins, including the potential induction of HtrA3 expression. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin triggers ER stress and the unfolded protein response, which can lead to the specific upregulation of genes involved in protein folding and degradation, including the potential stimulation of HtrA3 expression to mitigate misfolded protein accumulation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin specifically induces ER calcium depletion, which activates the unfolded protein response, potentially leading to the upregulation of genes like HtrA3 that participate in cellular recovery mechanisms. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, through its glucocorticoid receptor-mediated action, can induce the expression of genes that modulate inflammation and immune responses, which may include stimulating the expression of proteases such as HtrA3. | ||||||