HSV-1 ICP8 Activators
The chemical class of HSV-1 ICP8 Activators comprises a range of compounds that could influence the activity of ICP8, a crucial DNA-binding protein in the replication of herpes simplex virus type 1, indirectly. ICP8 is integral to viral replication and its modulation is intricately linked to both viral mechanisms and host cell interactions.
Compounds such as Acyclovir, Ganciclovir, Valacyclovir, Foscarnet, and Cidofovir demonstrate their ability to indirectly influence ICP8 activity through their roles in targeting viral DNA replication. These antiviral drugs, by inhibiting viral DNA polymerase or disrupting DNA synthesis, affect the replication process in which ICP8 is involved. This represents a mechanism through which the replication efficiency and, consequently, the activity of ICP8 can be indirectly modulated. Additionally, compounds like Forskolin and Phorbol 12-myristate 13-acetate (PMA), which influence cellular signaling pathways, could indirectly affect ICP8 by altering the intracellular environment and signaling cascades within the host cell.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acyclovir | 59277-89-3 | sc-202906 sc-202906A | 50 mg 500 mg | $147.00 $922.00 | 2 | |
An antiviral drug, could indirectly affect ICP8 by targeting viral DNA polymerase and disrupting DNA replication. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Increases cAMP levels, potentially influencing cellular pathways that might indirectly affect ICP8. | ||||||
Ganciclovir | 82410-32-0 | sc-203963 sc-203963A | 50 mg 250 mg | $228.00 $413.00 | 1 | |
Targets viral DNA polymerases, could indirectly affect ICP8 activity through inhibition of viral DNA synthesis. | ||||||
Valacyclovir Hydrochloride | 124832-27-5 | sc-204937 sc-204937A | 50 mg 100 mg | $117.00 $150.00 | ||
A prodrug of acyclovir, might influence ICP8 indirectly through its antiviral activity. | ||||||
Foscarnet sodium | 63585-09-1 | sc-205330 sc-205330A | 1 g 5 g | $186.00 $663.00 | ||
Inhibits viral DNA polymerase, potentially affecting ICP8 by disrupting viral DNA replication. | ||||||
Cidofovir | 113852-37-2 | sc-482141 | 50 mg | $135.00 | ||
An antiviral drug, could indirectly affect ICP8 through inhibition of viral DNA replication. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC), potentially affecting cellular signaling pathways that indirectly influence ICP8. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Influences various cellular signaling pathways, potentially modulating ICP8 activity indirectly. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A component of green tea, has antiviral properties, might indirectly influence ICP8. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Affects various signaling pathways, potentially modulating ICP8 activity indirectly. | ||||||