Valacyclovir Hydrochloride (CAS 124832-27-5)
QUICK LINKS
Valacyclovir hydrochloride is an antiviral compound intricately linked to acyclovir in its mechanism of action against herpesviruses. In biochemical pathways, it undergoes enzymatic conversion to acyclovir and L-valine, facilitated by specific esterases. This conversion unleashes acyclovir′s potent ability to thwart viral DNA polymerase, an enzyme pivotal for viral DNA replication. The selectivity of acyclovir′s action stems from its phosphorylation by virus-encoded thymidine kinase, transforming it into a formidable inhibitor that competes with natural nucleosides. This interaction disrupts the normal elongation of the viral DNA chain, effectively curbing viral replication. The biochemical transformation that valacyclovir hydrochloride undergoes not only serves as a sophisticated means of delivering acyclovir into the relevant biochemical pathways but also significantly boosts its bioavailability. This makes valacyclovir hydrochloride a focal point in virology research for its role in deciphering the lifecycle of herpesviruses and investigating the intricate mechanisms of viral replication inhibition.
Valacyclovir Hydrochloride (CAS 124832-27-5) References
- Stability of valacyclovir hydrochloride in extemporaneously prepared oral liquids. | Fish, DN., et al. 1999. Am J Health Syst Pharm. 56: 1957-60. PMID: 10554914
- Valacyclovir hydrochloride therapy and thrombotic thrombocytopenic purpura in an HIV-infected patient. | Rivaud, E., et al. 2000. Arch Intern Med. 160: 1705-6. PMID: 10847274
- Outcome of treatment with valacyclovir and prednisone in patients with Bell's palsy. | Axelsson, S., et al. 2003. Ann Otol Rhinol Laryngol. 112: 197-201. PMID: 12656408
- The treatment of herpes simplex infections: an evidence-based review. | Cernik, C., et al. 2008. Arch Intern Med. 168: 1137-44. PMID: 18541820
- Analysis of the antiviral drugs acyclovir and valacyclovir-hydrochloride in tsetse flies (Glossina pallidipes) using LC-MSMS. | Sasanya, JJ., et al. 2010. J Chromatogr B Analyt Technol Biomed Life Sci. 878: 2384-90. PMID: 20719583
- Incidence of postherpetic neuralgia after combination treatment with gabapentin and valacyclovir in patients with acute herpes zoster: open-label study. | Lapolla, W., et al. 2011. Arch Dermatol. 147: 901-7. PMID: 21482862
- Floating microspheres of valacyclovir HCl: Formulation, optimization, characterization, in vitro and in vivo floatability studies. | Goswami, N., et al. 2012. J Pharm Bioallied Sci. 4: S8-9. PMID: 23066217
- Kinetic Study of the Alkaline Degradation of Oseltamivir Phosphate and Valacyclovir Hydrochloride using Validated Stability Indicating HPLC. | Al-Bagary, RI., et al. 2014. Anal Chem Insights. 9: 41-8. PMID: 24932100
- Formulation development, optimization, and evaluation of sustained release tablet of valacyclovir hydrochloride by combined approach of floating and swelling for better gastric retention. | Upadhyay, P., et al. 2014. Drug Deliv Transl Res. 4: 452-64. PMID: 25787207
- Low-Dose Valacyclovir for Cytomegalovirus Infection Prophylaxis After a Heart Transplant. | Kervan, U., et al. 2016. Exp Clin Transplant. 14: 551-554. PMID: 26976362
- Acute renal injury induced by valacyclovir hydrochloride: A case report. | Zhang, Y., et al. 2016. Exp Ther Med. 12: 4025-4028. PMID: 28101180
- Novel Application of Hot Melt Extrusion Technology for Preparation and Evaluation of Valacyclovir Hydrochloride Ocular Inserts. | Shadambikar, G., et al. 2021. AAPS PharmSciTech. 22: 48. PMID: 33447869
- Kinetics and mechanistic investigations on antiviral drug-valacyclovir hydrochloride by heptavalent alkaline permanganate. | Tuwar, SM. and Hanabaratti, RM. 2021. J Chem Sci (Bangalore). 133: 114. PMID: 34751205
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Valacyclovir Hydrochloride, 50 mg | sc-204937 | 50 mg | $117.00 | |||
Valacyclovir Hydrochloride, 100 mg | sc-204937A | 100 mg | $150.00 |