Molecular structure of Ganciclovir, CAS Number: 82410-32-0
Ganciclovir (CAS 82410-32-0)
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Application:
Ganciclovir is A nucleoside analog structurally related to Acyclovir
CAS Number:
82410-32-0
Purity:
≥99%
Molecular Weight:
255.2
Molecular Formula:
C9H13N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ganciclovir is a nucleoside analog structurally related to Acyclovir that acts as a prodrug activated by phosphorylation. Ganciclovir has been used in the study of "suicide" gene therapy in cancer research, where upon expression of a viral suicide gene encoding herpes simplex virus, thymidine kinase (TK), the non-toxic prodrug ganciclovir, is converted to an active phosphorylated analog that can be incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. Causes an irreversible cell cycle arrest at the G2/M checkpoint. Ganciclovir has also been used to study the loss of telomeres and to evaluate sensitivity of viruses to antiviral agents.
Ganciclovir (CAS 82410-32-0) References
- Ganciclovir inhibits lymphocyte proliferation by impairing DNA synthesis. | Battiwalla, M., et al. 2007. Biol Blood Marrow Transplant. 13: 765-70. PMID: 17580254
- Topical ganciclovir in the treatment of acute herpetic keratitis. | Tabbara, KF. and Al Balushi, N. 2010. Clin Ophthalmol. 4: 905-12. PMID: 20823931
- Pharmacokinetics of ganciclovir and valganciclovir in the adult horse. | Carmichael, RJ., et al. 2013. J Vet Pharmacol Ther. 36: 441-9. PMID: 23301502
- The antiviral drug ganciclovir does not inhibit microglial proliferation and activation. | Skripuletz, T., et al. 2015. Sci Rep. 5: 14935. PMID: 26447351
- Pharmacokinetics and tissue diffusion of ganciclovir in mice and rats. | Boujemla, I., et al. 2016. Antiviral Res. 132: 111-5. PMID: 27260855
- Ganciclovir-induced ataxia and encephalopathy. | Möhlmann, MC., et al. 2016. Neth J Med. 74: 449-450. PMID: 27966439
- Paediatric ganciclovir dosing in extracorporeal membrane oxygenation: Is standard dosing good enough? | Murphy, M., et al. 2020. J Clin Pharm Ther. 45: 218-220. PMID: 31545518
- In vitro efficacy of ganciclovir against feline herpesvirus type 1 and assessment of ocular tolerability in healthy cats. | Lewin, AC., et al. 2021. J Feline Med Surg. 23: 400-404. PMID: 32749191
- Presumed neonatal cytomegalovirus retinitis treated with intravenous ganciclovir. | Suganya, A., et al. 2020. Indian J Ophthalmol. 68: 1957-1958. PMID: 32823433
- Dose banding of intravenous ganciclovir: Banding scheme proposal and audit of toxicity and efficiency. | Rodriguez-Reyes, M., et al. 2021. J Clin Pharm Ther. 46: 767-771. PMID: 33421169
- Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing. | Chou, S., et al. 2021. Antiviral Res. 193: 105139. PMID: 34273445
- Ganciclovir Pharmacokinetics and Individualized Dosing Based on Covariate in Lung Transplant Recipients. | Dvořáčková, E., et al. 2022. Pharmaceutics. 14: PMID: 35214140
- A Case of Good Visual Outcome following Retinal Ganciclovir Toxicity. | Yien, L., et al. 2022. Ocul Immunol Inflamm. 1-3. PMID: 36084193
- Efficacy of ganciclovir versus foscarnet in ganciclovir-resistant cytomegalovirus retinitis: A case report. | Lee, HJ. and Woo, SJ. 2022. Eur J Ophthalmol. 11206721221136316. PMID: 36314436
Inhibitor of:
Adenovirus hexon protein, Adenovirus-5 hexon, CMV, CMV gB, CMV gH, CMV pp28, CMV pp52, CMV pp65, CMV pp72, CMV pp86, CMV UL94, DGUOK, DNA pol γ2, dNT-1, HERPUD2, HHV-6, HHV-8, HHV-8 B, HHV-8 gp64, HHV-8 K14, HSV-1, HSV-1 gC, HSV-1 ICP0, HSV-1 ICP27, HSV-1 ICP4, HSV-1 ICP4 Immediate Early Protein, HSV-1 Thymidine Kinase, HSV-1 VP16, HSV-2, HSV-2 gD, HSV-2 gE Envelope Protein, HSV-2 gG Envelope Protein, HSV-2 ICP10, HSV-2 ICP8 Major DNA binding protein, HSV-2 VP22, Human Herpesvirus 6 (HHV-6), KSHV ORF 62, Nucleoside Monophosphate Kinase, Olr252, Parvovirus, PNP2, QTRT1, Thymidine Kinase, Varicella Zoster Virus gpIII, Varicella Zoster Virus gpIV, Varicella Zoster Virus IV, VARS2, VZV gE, VZV IE62, and VZV thymidine kinase.Activator of:
Adenovirus-5 hexon, EBV Ea-R p85, HHV-6 p37 early antigen, HSV-1 gG, HSV-1 ICP4 Immediate Early Protein, HSV-1 ICP8, HSV-1 UL42, HSV-1 VP22, and HSV-2 gB.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ganciclovir, 50 mg | sc-203963 | 50 mg | $228.00 | |||
Ganciclovir, 250 mg | sc-203963A | 250 mg | $413.00 |