HSFY1 Inhibitors
HSFY1 inhibitors are a class of compounds that target the HSFY1 (Heat Shock Transcription Factor, Y-linked 1) protein. HSFY1 is part of the heat shock factor family, which plays a crucial role in regulating cellular responses to stress, particularly in relation to the expression of heat shock proteins (HSPs). These proteins are involved in protecting cells from stress by refolding damaged proteins and aiding in protein homeostasis. HSFY1 is predominantly expressed in male germ cells and is located on the Y chromosome. Inhibitors of HSFY1 disrupt its ability to regulate heat shock proteins, potentially influencing the cellular response to various environmental and intracellular stressors. By targeting HSFY1, these inhibitors interfere with its transcriptional regulatory activity, thereby affecting downstream processes linked to protein stabilization and cellular stress management.
In research, HSFY1 inhibitors are utilized to explore the role of HSFY1 in stress responses and reproductive biology. These inhibitors help scientists study how altering the expression of heat shock proteins impacts spermatogenesis and other processes related to male fertility. Additionally, HSFY1 inhibitors serve as tools for investigating the broader regulatory networks that control protein homeostasis under stress conditions. Through the inhibition of HSFY1, researchers can also probe the dynamics of heat shock response pathways, uncovering how cells manage protein folding, degradation, and repair mechanisms when facing proteotoxic stress. Understanding the specific role of HSFY1 in these processes provides valuable insights into the molecular mechanisms of stress resilience and protein regulation in cells.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This agent could demethylate cytosine bases within the HSFY1 promoter region, leading to a decrease in DNA methylation and potentially lifting repression off the gene, resulting in its increased transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A would inhibit histone deacetylase activity, leading to hyperacetylation of histones in the HSFY1 gene locus, which could disrupt chromatin compaction and decrease HSFY1 transcription. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid may lead to the accumulation of acetylated histones in the regulatory regions of HSFY1, which can interfere with the binding of repressive transcriptional machinery, thereby decreasing HSFY1 expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A chelates DNA and could preferentially bind to the GC-rich regions of the HSFY1 promoter, obstructing the binding of essential transcription factors required for HSFY1 transcription and reducing its expression. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram could inhibit the proteasomal activity, thereby potentially altering the degradation of specific transcription factors or co-activators necessary for the transcription of HSFY1, leading to its reduced expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, as a tyrosine kinase inhibitor, could downregulate tyrosine phosphorylation on key signaling proteins that are essential for the transcriptional activation of HSFY1, resulting in lower expression levels. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Through its antioxidant properties, Quercetin may downregulate oxidative stress pathways that, when activated, could promote the transcription of stress response genes including HSFY1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can bind to retinoic acid receptors and alter the transcription of genes involved in cell differentiation and proliferation, which may include the downregulation of HSFY1 expression. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 could inhibit MEK1/2, leading to a decrease in ERK1/2 phosphorylation and subsequent downregulation of transcription factors that drive HSFY1 transcription. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
By inhibiting PI3K, LY 294002 could reduce AKT phosphorylation and activity, leading to a decrease in the transcriptional activity of factors that control HSFY1 expression levels. | ||||||