HSFX2 Activators
Activators of HSFX2 influence a variety of cellular signaling pathways, resulting in the upregulation of this transcription factor's activity. Compounds that enhance intracellular cyclic AMP (cAMP) play a pivotal role by activating adenylate cyclase or inhibiting phosphodiesterases, leading to an accumulation of cAMP. This rise in cAMP activates protein kinase A (PKA), which is known to phosphorylate various transcription factors and coactivators, thereby potentially enhancing the activity of HSFX2 in the transcriptional response to stress. Similarly, beta-adrenergic agonists increase cAMP levels, further triggering PKA and promoting HSFX2 activity. In addition to cAMP modulation, calcium signaling also plays a significant role. Specific compounds act as ionophores, increasing intracellular calcium concentrations, which may activate calcium-dependent kinases, thereby influencing HSFX2 activity. These changes in calcium homeostasis can have a profound effect on stress response signaling cascades, leading to the activation of transcription factors related to HSFX2.
Furthermore, the activation of protein kinase C (PKC) through certain compounds could lead to the phosphorylation of proteins that are integral to the functioning of HSFX2. Other compounds that induce oxidative stress can stimulate the cellular defense mechanisms that HSFX2 is part of, thereby indirectly increasing its activity. The modulation of oxidative stress response pathways through polyphenols could also influence the activity of HSFX2 by affecting related signal transduction mechanisms. Additionally, activators that target the transient receptor potential vanilloid 1 (TRPV1) channels may indirectly enhance HSFX2 activity due to subsequent intracellular signaling events involving calcium ions. There are also activators that can prompt stress-activated protein kinases (SAPKs), potentially leading to the activation of HSFX2 as part of the cellular adaptation to environmental stresses.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels, which can enhance HSFX2 activity by promoting the phosphorylation of transcription factors. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A beta-adrenergic agonist that increases cAMP levels, potentially enhancing HSFX2 activity through the cAMP-dependent protein kinase A (PKA) pathway. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
A non-selective phosphodiesterase inhibitor that prevents cAMP degradation, which may promote HSFX2 activity via sustained PKA signaling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC) which could lead to the activation of HSFX2 by phosphorylating related transcription factors or coactivators. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Increases cytosolic calcium levels, potentially leading to the activation of HSFX2 through calcium-sensitive signaling pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A calcium ionophore that elevates intracellular calcium, which may activate HSFX2 by stimulating calcium-dependent protein kinases. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cAMP analog that activates PKA, possibly leading to enhanced HSFX2 activity by phosphorylation of transcriptional machinery. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
A selective phosphodiesterase 4 inhibitor that raises cAMP levels, potentially enhancing HSFX2 activity by PKA activation in the signaling cascade. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A polyphenol that may activate HSFX2 by modulating signal transduction pathways involved in oxidative stress responses. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Activates TRPV1 channels, potentially leading to enhanced HSFX2 activity through secondary messenger pathways that respond to increased calcium ions. | ||||||