Hrnbp3 Activators
HRNBP3 Activators are a collection of chemical compounds that enhance the functional activity of HRNBP3 through various pathways and cellular mechanisms. Forskolin, by elevating cAMP levels, leads to PKA activation, which is known to phosphorylate SR proteins involved in alternative splicing, a key process regulated by HRNBP3. Ionomycin increases intracellular calcium levels, activating CaMK, which can modulate proteins in RNA processing, thereby indirectly enhancing HRNBP3's activity. PMA, through PKC activation, affects the phosphorylation status of RNA processing factors, subsequently enhancing HRNBP3's RNA-binding affinity and regulatory functions.
Glucokinase (GCK) Activators encompass a variety of compounds that enhance the enzyme's ability to catalyze the phosphorylation of glucose, a pivotal step in glycolysis and glucose homeostasis. Key physiological activators such as glucose itself bind directly to GCK, increasing its affinity for the substrate and enhancing its action in glycolytic pathways. Allosteric activators, such as fructose-1-phosphate, elevate GCK activity by improving substrate affinity, thereby accelerating glucose metabolism. Metabolites like sorbitol and mannose indirectly influence GCK by shifting the balance of competing phosphorylation reactions and generating intermediates that could modulate its activity. Similarly, glucosamine and N-Acetylglucosamine (GlcNAc) are metabolized to compounds that intersect with GCK's regulatory network, potentially affecting its function in glucose utilization.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that elevates intracellular calcium levels, thereby activating calcium/calmodulin-dependent protein kinase (CaMK), which can modulate the phosphorylation status of proteins involved in RNA binding and processing, indirectly enhancing the activity of HRNBP3. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC). PKC phosphorylation can influence the assembly of RNA processing factors, including the HRNBP3 protein, enhancing its RNA-binding capability and modulating its role in post-transcriptional gene regulation. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the PI3K/Akt signaling pathway, which can lead to the phosphorylation of various proteins involved in mRNA stability and localization. HRNBP3, as a regulator of mRNA processing, may have its function enhanced by the pathway's downstream effects on RNA metabolism. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits several protein kinases, which can reduce competitive phosphorylation of RNA-binding proteins. This creates a favorable environment for HRNBP3 to bind its target mRNAs more effectively, thus enhancing its role in mRNA metabolism. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that can lead to changes in gene expression patterns. This alteration may increase the expression of genes coding for proteins that interact with HRNBP3, potentially enhancing its activity in RNA splicing and processing. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor which can lead to changes in chromatin structure, potentially increasing accessibility to genes involved in RNA processing and indirectly enhancing HRNBP3 function through increased expression of these genes. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $149.00 $12495.00 | 18 | |
Oligomycin is an inhibitor of ATP synthase which can lead to altered cellular energy states. This may influence the activity of ATP-dependent RNA helicases, indirectly enhancing HRNBP3's role in mRNA export and metabolism due to changes in RNA secondary structure. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts the Golgi apparatus, which can lead to a cellular stress response, including the stress granule formation. HRNBP3 is known to localize to stress granules, and its activity in mRNA sorting and stabilization could be enhanced as part of the stress response. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG is an Hsp90 inhibitor that can disrupt the function of several client proteins, potentially altering the cellular signaling landscape. This disruption could enhance HRNBP3 activity by inducing a stress response that favors the assembly of RNA processing bodies where HRNBP3 functions. | ||||||
Sodium arsenite, 0.1N Standardized Solution | 7784-46-5 | sc-301816 | 500 ml | $130.00 | 4 | |
Sodium arsenite induces oxidative stress, which can lead to the formation of stress granules. HRNBP3, which localizes to these granules, may have its activity in mRNA stabilization and sorting enhanced as a protective cellular response to the stress. | ||||||