hRIF Inhibitors
hRIF inhibitors are a class of compounds that target the human Replication Initiation Factor (hRIF), a critical component involved in the initiation of DNA replication. hRIF plays a crucial role in the regulation of DNA replication by ensuring that the replication process starts at the correct time and location within the cell cycle. It is responsible for stabilizing replication origins and interacting with other replication proteins to form the pre-replication complex. By inhibiting hRIF, these compounds interfere with the precise control of replication initiation, leading to disruptions in DNA synthesis. This inhibition can be used to study the molecular mechanisms that govern DNA replication and cellular division.
In research, hRIF inhibitors serve as valuable tools for understanding the cell cycle and the regulation of DNA replication in various cell types. These inhibitors are used in experimental settings to investigate the timing and coordination of replication processes, particularly during the S-phase of the cell cycle. By selectively blocking hRIF activity, researchers can analyze the effects on DNA replication origins, replication fork stability, and the overall replication machinery. The insights gained from studying hRIF inhibitors provide critical information on how cells maintain genomic integrity and respond to DNA replication stress. These studies are important for uncovering the underlying biology of cell proliferation and the maintenance of genomic stability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor may directly lead to the hypomethylation of the hRIF gene promoter, resulting in transcriptional silencing of the hRIF gene. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
By inhibiting histone deacetylase activity, Trichostatin A could increase acetylation levels at the hRIF locus, potentially repressing hRIF transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to downregulate the expression of specific genes by interfering with transcription factor binding to DNA, which may include the binding sites upstream of the hRIF gene. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may suppress hRIF expression by activating sirtuins that deacetylate histones tied to the hRIF gene, leading to compact chromatin and decreased transcription. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
This compound could initiate the transcription of a different set of genes involved in cellular defense mechanisms, which might include repressors of the hRIF gene. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram may indirectly decrease hRIF expression by disrupting the proteasome-mediated degradation of transcriptional repressors of the hRIF gene. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
As a MEK inhibitor, PD 98059 could decrease hRIF transcription by preventing the activation of transcription factors that promote hRIF gene expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
This phosphoinositide 3-kinase (PI3K) inhibitor may downregulate hRIF expression by attenuating the AKT signaling pathway, which is often involved in transcriptional regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin could reduce hRIF protein levels by inhibiting mTOR, a central regulator of protein synthesis, thus indirectly decreasing hRIF gene expression through feedback mechanisms. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
By inhibiting the proteasome, Bortezomib could increase the cellular levels of transcriptional repressors of hRIF, leading to reduced expression of the hRIF gene. | ||||||