HOS Inhibitors
HOS inhibitors represent a sophisticated class of chemicals designed to modulate the expression and function of the HOS protein, primarily by targeting the intricate Wnt signaling pathway. Niclosamide, a direct HOS inhibitor, disrupts Wnt/β-catenin signaling by specifically inhibiting TCF/LEF transcriptional activity, negatively impacting cellular processes dependent on Wnt signaling. IWP-2 and LGK-974 act as direct HOS inhibitors by blocking Porcupine, essential for Wnt ligand secretion, and stabilizing Axin1 and Axin2, respectively. These actions result in disrupted Wnt ligand processing and secretion, leading to downregulated HOS expression and modulation of Wnt-mediated cellular processes. Indirect HOS inhibitors, such as XAV939 and PRI-724, target the Wnt/β-catenin pathway by modulating β-catenin interactions. XAV939 stabilizes Axin1 and Axin2, promoting the degradation of β-catenin, while PRI-724 disrupts the interaction between β-catenin and CBP, altering β-catenin-dependent transcription. Additionally, compounds like CWP232291 and IWR-1 act as direct HOS inhibitors by interfering with the interaction between β-catenin and TCF/LEF transcription factors.
The tankyrase inhibitors, JW55 and IWR-1, indirectly inhibit HOS by stabilizing Axin1 and Axin2, leading to the degradation of β-catenin and subsequent downregulation of Wnt/β-catenin signaling. Moreover, KYA1797K, a direct HOS inhibitor, disrupts the binding of β-catenin to TCF/LEF transcription factors, inhibiting β-catenin-dependent transcription and influencing cellular processes associated with Wnt signaling. CGP049090 and Wnt-C59, both Porcupine inhibitors, directly inhibit HOS by preventing Wnt ligand acylation and secretion, resulting in decreased Wnt signaling and modulation of HOS expression. The Hedgehog pathway modulator, ETC-159, indirectly influences HOS by inhibiting Smoothened, disrupting Hedgehog signaling, and subsequently impacting Wnt signaling. Collectively, HOS inhibitors offer a nuanced approach to understanding and manipulating the complex regulatory networks involved in Wnt signaling, providing valuable insights into the intricate molecular mechanisms governing cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $37.00 $77.00 $184.00 $510.00 $1224.00 $5814.00 | 8 | |
Niclosamide, an anthelmintic drug, acts as a direct HOS inhibitor by disrupting the Wnt/β-catenin signaling pathway. It specifically inhibits TCF/LEF transcriptional activity downstream of β-catenin, thereby modulating the expression of HOS and negatively impacting Wnt-mediated cellular processes. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
IWP-2, a small molecule, directly inhibits HOS by blocking Porcupine, an acyltransferase essential for Wnt ligand secretion. This inhibition disrupts Wnt ligand processing and secretion, leading to reduced Wnt signaling and subsequent downregulation of HOS expression, influencing cellular functions dependent on Wnt signaling. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
XAV939, a tankyrase inhibitor, indirectly inhibits HOS by modulating the Wnt/β-catenin pathway. It stabilizes Axin1 and Axin2, promoting the formation of the β-catenin destruction complex. Consequently, XAV939 enhances the degradation of β-catenin, negatively regulating Wnt signaling and impacting HOS expression and associated cellular processes. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $352.00 $1270.00 | 2 | |
LGK-974 is a Porcupine inhibitor that directly inhibits HOS by preventing Wnt ligand acylation and secretion. This disruption of Wnt ligand processing leads to decreased Wnt signaling and subsequent downregulation of HOS expression, influencing cellular functions dependent on Wnt-mediated signaling pathways. | ||||||
PRI-724 | 1422253-38-0 | sc-507535 | 25 mg | $255.00 | ||
PRI-724 is a CBP/β-catenin inhibitor that indirectly inhibits HOS by disrupting the interaction between β-catenin and CBP. This inhibition alters the transcriptional regulation of Wnt target genes, including HOS, influencing cellular processes dependent on Wnt signaling and β-catenin-dependent transcription. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $132.00 | 19 | |
IWR-1, a tankyrase inhibitor, indirectly inhibits HOS by stabilizing Axin1 and Axin2, promoting the degradation of β-catenin. This leads to downregulated Wnt/β-catenin signaling and subsequent modulation of HOS expression, influencing cellular processes associated with Wnt-mediated signaling pathways. | ||||||
JW 55 | 664993-53-7 | sc-364517 sc-364517A | 10 mg 50 mg | $172.00 $726.00 | ||
JW55, a tankyrase inhibitor, indirectly inhibits HOS by stabilizing Axin1 and Axin2, promoting the degradation of β-catenin. This leads to downregulated Wnt/β-catenin signaling and subsequent modulation of HOS expression, influencing cellular processes associated with Wnt-mediated signaling pathways. | ||||||
Cercosporin | 35082-49-6 | sc-255013 | 5 mg | $450.00 | 1 | |
Cercosporin, a Porcupine inhibitor, directly inhibits HOS by preventing Wnt ligand acylation and secretion. This disruption of Wnt ligand processing leads to decreased Wnt signaling and subsequent downregulation of HOS expression, influencing cellular functions dependent on Wnt-mediated signaling pathways. | ||||||
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $210.00 $320.00 $1250.00 | 1 | |
Wnt-C59, a Porcupine inhibitor, directly inhibits HOS by preventing Wnt ligand acylation and secretion. This disruption of Wnt ligand processing leads to decreased Wnt signaling and subsequent downregulation of HOS expression, influencing cellular functions dependent on Wnt-mediated signaling pathways. | ||||||
ETC-159 | 1638250-96-0 | sc-507415 | 5 mg | $90.00 | ||
ETC-159, a Smoothened inhibitor, indirectly inhibits HOS by modulating the Hedgehog signaling pathway. By inhibiting Smoothened, ETC-159 disrupts Hedgehog signaling, leading to downstream effects on Wnt signaling and subsequent downregulation of HOS expression, impacting cellular processes associated with Wnt and Hedgehog crosstalk. | ||||||