Molecular structure of ETC-159, CAS Number: 1638250-96-0
ETC-159 (CAS 1638250-96-0)
Alternate Names:
1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-N-(6-phenyl-3-pyridazinyl)-7H-purine-7-acetamide
CAS Number:
1638250-96-0
Molecular Weight:
391.4
Molecular Formula:
C19H17N7O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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ETC-159 (CAS 1638250-96-0) References
- Wnt addiction of genetically defined cancers reversed by PORCN inhibition. | Madan, B., et al. 2016. Oncogene. 35: 2197-207. PMID: 26257057
- Molecular genetics and targeted therapy of WNT-related human diseases (Review). | Katoh, M. and Katoh, M. 2017. Int J Mol Med. 40: 587-606. PMID: 28731148
- PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers. | Zhong, Z., et al. 2019. Oncogene. 38: 6662-6677. PMID: 31391551
- Broad regulation of gene isoform expression by Wnt signaling in cancer. | Idris, M., et al. 2019. RNA. 25: 1696-1713. PMID: 31506381
- Porcupine inhibitors: Novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway. | Shah, K., et al. 2021. Pharmacol Res. 167: 105532. PMID: 33677106
- Amelioration of bone fragility by pulsed electromagnetic fields in type 2 diabetic KK-Ay mice involving Wnt/β-catenin signaling. | Shao, X., et al. 2021. Am J Physiol Endocrinol Metab. 320: E951-E966. PMID: 33719588
- Recent updates on Wnt signaling modulators: a patent review (2014-2020). | Goswami, VG. and Patel, BD. 2021. Expert Opin Ther Pat. 31: 1009-1043. PMID: 34128760
- Structural model of human PORCN illuminates disease-associated variants and drug-binding sites. | Yu, J., et al. 2021. J Cell Sci. 134: PMID: 34817055
- ETC-159, an Upstream Wnt inhibitor, Induces Tumour Necrosis via Modulation of Angiogenesis in Osteosarcoma. | Chua, K., et al. 2023. Int J Mol Sci. 24: PMID: 36902186
- Examination of Wnt signaling as a therapeutic target for pancreatic ductal adenocarcinoma (PDAC) using a pancreatic tumor organoid library (PTOL). | Hawkins, HJ., et al. 2024. PLoS One. 19: e0298808. PMID: 38598488
Inhibitor of:
C12orf51, HOS, LEF-1, LGR5, MESDC2, Notum, PORCN, TMEM170B, Vangl1, WDR27, Wnt-14, and WTIP.Activator of:
C-TAK1L.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ETC-159, 5 mg | sc-507415 | 5 mg | $90.00 |