HNP Inhibitors
HNP inhibitors refer to a class of chemical compounds that specifically inhibit the activity of human neutrophil peptides (HNPs). HNPs, part of the alpha-defensin family, are small, cationic peptides predominantly found in neutrophils, which play a key role in the immune response. HNPs have been shown to exhibit antimicrobial activity by interacting with microbial membranes, disrupting their integrity, and leading to cell lysis. The inhibitors of HNPs are designed to block or neutralize their activity, thereby preventing the peptides from exerting their membrane-disruptive effects. HNP inhibitors typically achieve this by binding to the active site or the binding interface of the peptide, inhibiting its interaction with target membranes or other biomolecules.
Structurally, HNP inhibitors are diverse, often encompassing small molecules, peptides, or peptidomimetics designed to interact with specific functional groups or domains of the HNP molecules. These inhibitors often exploit the charged and amphipathic nature of HNPs to achieve selective inhibition. Many HNP inhibitors are designed based on the structure-function relationships of HNPs, targeting key amino acids critical for their activity. The design and development of HNP inhibitors also involve understanding the conformational dynamics of HNPs, including how they interact with different molecular environments such as lipids, proteins, and nucleic acids. By fine-tuning molecular interactions, researchers can develop inhibitors that precisely modulate HNP activity in various experimental contexts, which is valuable for studying the biochemical roles of these peptides.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a synthetic glucocorticoid, may downregulate HNP expression by attenuating the transcription of inflammatory cytokines in neutrophils, which are crucial for HNP gene activation. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin may decrease HNP expression by inhibiting the cyclooxygenase pathway and reducing the production of prostaglandins that stimulate neutrophil activity and HNP secretion. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin might decrease HNP expression through the suppression of NF-κB pathway, a key transcription factor involved in the induction of HNP genes during inflammatory responses. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may reduce HNP expression by downregulating pro-inflammatory signaling pathways, including NF-κB, which orchestrates the expression of various immune response genes in neutrophils. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin may inhibit HNP expression by downregulating interleukin-1β, a cytokine that prompts the synthesis of HNPs in response to microbial invasion. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
By selectively inhibiting inosine monophosphate dehydrogenase, Mycophenolic acid could indirectly decrease HNP expression by reducing proliferation of T and B cells, which are part of the immune signaling cascade. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
Sulfasalazine may inhibit HNP expression by reducing the release of pro-inflammatory mediators that stimulate neutrophils, which are the primary producers of HNPs. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate has the potential to reduce HNP expression by inhibiting the activation of NF-κB and AP-1, transcription factors that upregulate genes encoding HNPs. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Thalidomide might inhibit HNP expression by reducing TNF-α production, a cytokine that can enhance neutrophil responses and HNP gene activation. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Hydroxychloroquine could decrease HNP expression by accumulating in neutrophilic lysosomes, altering pH, and thereby inhibiting processes crucial for HNP synthesis. | ||||||