Date published: 2025-11-26

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HNMT Inhibitors

HNMT inhibitors belong to a class of chemical compounds that specifically target and inhibit the activity of Histamine N-methyltransferase (HNMT). HNMT is an enzyme responsible for the inactivation of histamine, a biogenic amine involved in various physiological processes, by transferring a methyl group to it, resulting in the formation of N-methylhistamine. By inhibiting HNMT, these compounds interfere with the natural enzymatic process of histamine metabolism. As a consequence, the levels of histamine in the body may be affected, leading to alterations in histamine-mediated responses. HNMT inhibitors can vary in their chemical structures and may be found innatural sources or synthesized through chemical processes. Researchers investigate HNMT inhibitors to gain insights into the role of histamine metabolism in different biological systems and explore their applications in various contexts. It is important to continue studying and understanding the properties and mechanisms of these inhibitors to advance our knowledge of histamine regulation and its impact on physiological processes.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Metoprine

7761-45-7sc-484327
25 mg
$352.00
(0)

Metoprine is a known HNMT inhibitor that has been used in research settings to investigate the role of histamine metabolism in various physiological processes.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$108.00
$245.00
$918.00
$49.00
33
(2)

Quercetin is a natural flavonoid found in various fruits and vegetables. It has been reported to inhibit HNMT activity and modulate histamine levels.

Chlorpromazine

50-53-3sc-357313
sc-357313A
5 g
25 g
$60.00
$108.00
21
(1)

Chlorpromazine, a well-known antipsychotic agent in research, has been found to inhibit HNMT activity, leading to increased histamine levels.

Clozapine

5786-21-0sc-200402
sc-200402A
50 mg
500 mg
$68.00
$357.00
11
(1)

Clozapine, another antipsychotic drug, has been shown to inhibit HNMT activity and affect histamine metabolism.

Diphenhydramine hydrochloride

147-24-0sc-204729
sc-204729A
sc-204729B
10 g
25 g
100 g
$51.00
$82.00
$122.00
4
(1)

Diphenhydramine is an antihistamine drug that also possesses inhibitory effects on HNMT, leading to altered histamine levels.

Metoprolol Tartrate

56392-17-7sc-205751
sc-205751A
5 g
25 g
$105.00
$238.00
3
(1)

Metoprolol, a beta-blocker used for hypertension and other cardiovascular conditions, has been found to inhibit HNMT activity.

Ranitidine

66357-35-5sc-203679
1 g
$189.00
(1)

Ranitidine, an agent in research used to reduce stomach acid production, has been reported to inhibit HNMT and influence histamine levels.

Cimetidine

51481-61-9sc-202996
sc-202996A
5 g
10 g
$62.00
$86.00
1
(1)

Cimetidine has shown inhibitory effects on HNMT activity.

Trifluoperazine Dihydrochloride

440-17-5sc-201498
sc-201498A
1 g
5 g
$56.00
$99.00
9
(1)

Trifluoperazine is an antipsychotic drug that has been found to inhibit HNMT and impact histamine metabolism.

S(−)-Carbidopa

28860-95-9sc-200749
sc-200749A
25 mg
100 mg
$94.00
$270.00
5
(0)

Carbidopa has been reported to inhibit HNMT activity.