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Metoprolol Tartrate (CAS 56392-17-7)

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Alternate Names:
1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)- amino]-2-propanol tartrate; Beloc; Betaloc; Lopressor; Prelis; Seloken; Selopral; Selo-Zok
Application:
Metoprolol Tartrate is a b1-Adrenergic blocker
CAS Number:
56392-17-7
Purity:
≥98%
Molecular Weight:
684.82
Molecular Formula:
C34H56N2O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Metoprolol tartrate is a compound employed in research focused on cardiovascular function and the mechanisms of adrenergic receptor regulation. It is used to study the effects of beta-adrenergic blockade on phenomena such as heart rate variability, myocardial oxygen consumption, and cardiac electrophysiology. Metoprolol tartrate is also a subject of interest in research where its effects on enzyme activity and receptor binding are analyzed to understand the intricacies of signal transduction in cardiomyocytes. Additionally, it is used in experimental models to investigate the role of beta-blockers in the modulation of the autonomic nervous system and its impact on cardiovascular health.


Metoprolol Tartrate (CAS 56392-17-7) References

  1. Different effects of the beta-adrenoceptor antagonists celiprolol and metoprolol on vascular structure and function in long-term type I diabetic rats.  |  Olbrich, A., et al. 1999. J Cardiovasc Pharmacol. 33: 193-203. PMID: 10028926
  2. Metoprolol: a review of its use in chronic heart failure.  |  Prakash, A. and Markham, A. 2000. Drugs. 60: 647-78. PMID: 11030472
  3. β-blockers: a review of their pharmacological and physiological diversity in hypertension.  |  Ripley, TL. and Saseen, JJ. 2014. Ann Pharmacother. 48: 723-33. PMID: 24687542
  4. Quercetin declines plasma exposure of metoprolol tartrate in the rat model.  |  Challa, SR., et al. 2014. J Adv Pharm Technol Res. 5: 185-90. PMID: 25364697
  5. Synchronous delivery of felodipine and metoprolol tartrate using monolithic osmotic pump technology.  |  Zhao, S., et al. 2016. Drug Dev Ind Pharm. 42: 1723-31. PMID: 27074758
  6. Formulation and evaluation of controlled release ethylcellulose and polyethylene glycol microspheres containing metoprolol tartrate.  |  Malipeddi, VR., et al. 2016. Interv Med Appl Sci. 8: 60-67. PMID: 28386461
  7. Assessment of the safety of intravitreal injection of metoprolol tartrate in rabbits.  |  de Paiva, MRB., et al. 2021. Doc Ophthalmol. 142: 75-85. PMID: 32623534
  8. Fundamental Investigations into Metoprolol Tartrate Deposition on Orodispersible Films by Inkjet Printing for Individualised Drug Dosing.  |  Kiefer, O., et al. 2021. Pharmaceutics. 13: PMID: 33578818
  9. Sensitive Analysis of Metoprolol Tartrate and Diltiazem Hydrochloride in Human Serum by Capillary Zone Electrophoresis Combining on Column Field-Amplified Sample Injection.  |  Li, N., et al. 2021. J Chromatogr Sci. 59: 465-472. PMID: 33675354
  10. Pharmacokinetics and pharmacodynamics of oral and intravenous metoprolol tartrate in clinically healthy horses.  |  Luethy, D., et al. 2022. J Vet Pharmacol Ther. 45: 177-187. PMID: 34913168
  11. Effect of metoprolol tartrate tablets and recombinant human B-type natriuretic peptide on the sudden cardiac death and malignant arrhythmias in patients with acute myocardial infarction and heart failure.  |  Liu, C., et al. 2021. Pak J Pharm Sci. 34: 2473-2478. PMID: 35039262
  12. Role of hesperidin and fresh orange juice in altering the bioavailability of beta-blocker, metoprolol tartrate. An in vivo model.  |  Salam, R., et al. 2022. Xenobiotica. 52: 295-300. PMID: 35443873
  13. Identification of Metoprolol Tartrate-Derived Reactive Metabolites Possibly Correlated with Its Cytotoxicity.  |  Li, X., et al. 2022. Chem Res Toxicol. 35: 1059-1069. PMID: 35575346
  14. Efficacy and safety of Wenxin Keli combined with metoprolol tartrate in the treatment of premature ventricular contractions: A systematic review and meta-analysis.  |  Huang, P., et al. 2022. Front Cardiovasc Med. 9: 952657. PMID: 35966568
  15. Concentration-effect relationship of l-propranolol and metoprolol in spontaneous hypertensive rats after exercise-induced tachycardia.  |  Brynne, L., et al. 1998. J Pharmacol Exp Ther. 286: 1152-8. PMID: 9732372

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Metoprolol Tartrate, 5 g

sc-205751
5 g
$105.00

Metoprolol Tartrate, 25 g

sc-205751A
25 g
$238.00

für welche Beschwerden wird das Medikament genommen?

Asked by: Whoopi
Vielen Dank für Ihre Anfrage und Ihr Interesse an diesem Produkt. Alle unsere Produkte sind ausschließlich für Forschungszwecke empfohlen. Unsere Produkte sind nicht für diagnostische oder therapeutische Zwecke zugelassen. Für weitere Informationen wenden Sie sich bitte an unseren Technischen Service in unserem Europäischen Supportbüro in Heidelberg. Sie erreichen uns telefonisch unter 06221 4503 0, per email an: europe@scbt.com oder per Live-Chat auf unserer Webseite www.scbt.com Wir freuen uns Ihnen weiterzuhelfen.
Answered by: Technical Support Europe
Date published: 2017-08-02
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Rated 5 out of 5 by from HarrellHarrell, R. et al. (PubMed 26388403) investigated the effects of the 1 antagonist, Metoprolol, on methamphetamine (METH)-induced changes in core temperature in the rat. Their findings suggest that one component of METH's temperature effects involves increasing core temperature at all ambient conditions via 1 receptors. -SCBT Publication Review
Date published: 2015-07-10
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Metoprolol Tartrate is rated 5.0 out of 5 by 1.
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