Histone cluster 1 H4K Inhibitors
Histone cluster 1 H4K Inhibitors represent a specialized category of chemical compounds designed to selectively inhibit the activity of histone cluster 1, focusing on the H4K subtype. Histones play a critical role in the organization of DNA within the nucleus, forming nucleosomes that serve as the structural foundation for chromatin. The H4K designation refers to a variant of histone H4, one of the core histones essential for nucleosome assembly. As a specific variant within histone cluster 1, H4K becomes a focal point for researchers seeking to unravel the complexities of chromatin dynamics and gene regulation.
The development of Histone cluster 1 H4K Inhibitors requires a comprehensive understanding of the structural characteristics of histone H4K and its specific role within chromatin organization. These inhibitors are meticulously crafted for specificity, aiming to selectively bind to key regions of Histone cluster 1 H4K and disrupt its normal functions. By employing these inhibitors in experimental contexts, researchers can explore the consequences of inhibiting this particular histone variant, providing valuable insights into chromatin remodeling and the intricate regulation of gene expression. The study of histones, including variants like H4K, significantly contributes to advancing our understanding of epigenetic mechanisms, offering crucial insights into the dynamic processes governing gene regulation and the complex orchestration of cellular functions at the chromatin level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 is a DNA methyltransferase inhibitor that may prevent the methylation of gene promoters, potentially affecting the transcription of genes such as histone genes. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine is a cytidine analog that incorporates into DNA and inhibits DNA methyltransferase, leading to hypomethylation of DNA and potentially affecting gene expression, including that of histones. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat is an HDAC inhibitor that can alter acetylation levels of histones, potentially impacting the expression of various genes, including histone genes. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat is a well-known HDAC inhibitor that can change the acetylation status of histones, affecting gene expression and potentially downregulating histone gene transcription. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide has been shown to inhibit the NF-κB pathway, which might influence the transcription of various genes, including those involved in cell cycle regulation and potentially histones. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is an HDAC inhibitor that can modify histone acetylation and thereby impact the expression of a wide array of genes, including histones. | ||||||
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
SAH is a product of S-adenosylmethionine-dependent methyltransferase reactions and can act as an inhibitor of these enzymes, potentially affecting histone methylation and gene expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is an HDAC inhibitor that can induce hyperacetylation of histones, leading to changes in gene expression patterns, which could include the histone genes. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A binds to GC-rich DNA sequences and can inhibit transcription factor binding to DNA, potentially reducing the expression of genes with these sequences, including certain histones. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
MS-275 is a selective HDAC inhibitor that has been shown to affect gene expression by altering histone acetylation, potentially including histone genes. | ||||||