Histone cluster 1 H4I Inhibitors
Histone cluster 1 H4I Inhibitors represent a specialized class of chemical compounds designed to selectively inhibit the activity of histone cluster 1, specifically targeting the H4I subtype. Histones are integral proteins in the organization of DNA within the nucleus, forming nucleosomes that serve as the structural foundation for chromatin. The H4I designation refers to a variant of histone H4, one of the core histones essential for nucleosome assembly. As a specific variant within histone cluster 1, H4I becomes a focal point for researchers seeking to unravel the complexities of chromatin dynamics and gene regulation.
The development of Histone cluster 1 H4I Inhibitors requires a detailed understanding of the structural characteristics of histone H4I and its specific role within chromatin organization. These inhibitors are meticulously designed for specificity, aiming to selectively bind to key regions of Histone cluster 1 H4I and disrupt its normal functions. By employing these inhibitors in experimental contexts, researchers can explore the consequences of inhibiting this particular histone variant, providing valuable insights into chromatin remodeling and the intricate regulation of gene expression. The study of histones, including variants like H4I, significantly contributes to advancing our understanding of epigenetic mechanisms, offering crucial insights into the dynamic processes governing gene regulation and the complex orchestration of cellular functions at the chromatin level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can inhibit acetaldehyde dehydrogenase and has been shown to have effects on the proteasome, potentially altering protein degradation pathways that might include factors regulating histone gene expression. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Anacardic acid has been found to inhibit histone acetyltransferase (HAT) activity, which could alter histone acetylation and thus affect transcription, including the expression of histone genes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to modulate various cellular processes and has been shown to inhibit histone acetyltransferase, potentially altering gene expression patterns including histone genes. | ||||||
Garcinol | 78824-30-3 | sc-200891 sc-200891A | 10 mg 50 mg | $124.00 $502.00 | 13 | |
Garcinol is an inhibitor of histone acetyltransferase, which can lead to changes in gene expression by affecting histone acetylation, possibly impacting histone gene expression. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib is a poly(ADP-ribose) polymerase (PARP) inhibitor, potentially affecting DNA repair and chromatin structure, which could indirectly influence histone gene expression. | ||||||
I-CBP112 | 1640282-31-0 | sc-507494 | 25 mg | $400.00 | ||
I-CBP112 is a selective CBP/p300 bromodomain inhibitor, which could affect histone acetylation and gene transcription, potentially including the expression of histone genes. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
I-BET151 is a BET bromodomain inhibitor that can modulate chromatin structure and gene expression, potentially affecting the transcription of histone genes. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 is a small molecule inhibitor of BET bromodomains, which can influence chromatin remodeling and gene expression, potentially reducing the expression of histone genes. | ||||||
Apicidin | 183506-66-3 | sc-202061 sc-202061A | 1 mg 5 mg | $110.00 $343.00 | 9 | |
Apicidin is an HDAC inhibitor that can affect chromatin acetylation and gene expression, which might include histone gene transcription. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
C646 is a selective p300/CPB histone acetyltransferase inhibitor, which might alter histone acetylation patterns and gene expression, potentially affecting histone gene expression. | ||||||