Hhip Activators
Hhip activators encompass a range of chemicals that can indirectly influence the activity of Hhip, a key regulatory component of the Hedgehog (Hh) signaling pathway. These activators do not directly interact with Hhip but modulate its activity through their effects on the Hh pathway and other related signaling cascades. The indirect activation of Hhip by these compounds reflects the complexity of signaling regulation and the integral role of Hhip in these processes.
Compounds like Cyclopamine, Vismodegib, and Sonidegib, known for their inhibitory action on Smoothened (SMO), a critical component of the Hh pathway, indirectly influence Hhip. By inhibiting SMO, these compounds can trigger compensatory mechanisms within the pathway, potentially leading to increased expression of Hhip as a form of feedback regulation. This response underscores the dynamic nature of cellular signaling, where inhibition of one component can lead to the upregulation of another to maintain homeostasis. Other chemicals, such as Vitamin D3, Retinoic Acid, Lithium Chloride, Nicotine, Curcumin, Quercetin, EGCG, Resveratrol, and Berberine, exert their effects on various signaling pathways, including the Hh pathway, thereby potentially influencing Hhip expression.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Cyclopamine, an inhibitor of the Smoothened (SMO) protein, indirectly influences Hhip by modulating the Hh pathway. Inhibition of SMO can lead to compensatory regulatory mechanisms that might increase Hhip expression as part of feedback regulation within the pathway. | ||||||
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $82.00 $158.00 | 1 | |
Vismodegib, another SMO inhibitor, similarly affects the Hh pathway. Its inhibition of SMO can indirectly upregulate Hhip as a compensatory response in the Hh signaling pathway. | ||||||
Erismodegib | 956697-53-3 | sc-396280 sc-396280A | 10 mg 100 mg | $255.00 $918.00 | ||
Sonidegib acts as an SMO inhibitor and can indirectly affect Hhip through similar mechanisms as other SMO inhibitors, potentially leading to an increase in Hhip expression. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 can influence various signaling pathways, including the Hh pathway. Its regulatory effects on cellular differentiation and proliferation might indirectly affect Hhip expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid, known for its role in gene expression and cell differentiation, can modulate the Hh signaling pathway. This modulation may lead to an indirect influence on Hhip expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride can inhibit GSK-3β, a component of the Wnt signaling pathway, which intersects with the Hh pathway. This inhibition might lead to indirect modulation of Hhip expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin affects multiple signaling pathways, including the Hh pathway. Its modulation of this pathway can lead to changes in Hhip expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, can modulate various signaling pathways. Its influence on the Hh pathway could indirectly affect Hhip expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a major component of green tea, has been shown to affect various signaling pathways, including the Hh pathway. This could lead to an indirect increase in Hhip expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can impact multiple signaling pathways. Its effect on the Hh pathway might indirectly influence Hhip expression. | ||||||