Hhip Inhibitors
Regarding the chemical class of HHIP inhibitors, these are primarily inhibitors of the hedgehog signaling pathway, which HHIP is a part of. The primary target of many of these inhibitors is Smoothened (SMO), a G protein-coupled receptor that plays a critical role in transducing the hedgehog signal. By inhibiting SMO, these compounds effectively suppress the downstream effects of the hedgehog pathway, including the modulation of HHIP activity or expression.
Most of these inhibitors, like Cyclopamine and Vismodegib, are small molecules that interact directly with the SMO protein, blocking its activity. This leads to a decrease in the hedgehog pathway signaling, which can indirectly influence HHIP. Others, such as GANT61, work further downstream by targeting GLI transcription factors, which are the ultimate effectors of the hedgehog signaling cascade. By inhibiting these factors, the transcription of hedgehog-responsive genes, potentially including HHIP, is also reduced.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Cyclopamine directly inhibits Smoothened (SMO), a protein in the hedgehog pathway, thus indirectly affecting HHIP activity. | ||||||
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $82.00 $158.00 | 1 | |
Vismodegib selectively binds to and inhibits SMO, thereby potentially influencing HHIP through the hedgehog signaling pathway. | ||||||
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $64.00 $131.00 $204.00 | 6 | |
GANT61 inhibits GLI1 and GLI2, downstream effectors in the hedgehog pathway, impacting HHIP regulation indirectly. | ||||||
Jervine | 469-59-0 | sc-200934 sc-200934A | 1 mg 5 mg | $66.00 $240.00 | 1 | |
Jervine antagonizes hedgehog signaling by inhibiting SMO, which can indirectly affect HHIP expression or activity. | ||||||
Saridegib | 1037210-93-7 | sc-507351 | 5 mg | $3500.00 | ||
Saridegib targets and inhibits SMO, likely influencing HHIP through modulation of the hedgehog pathway. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $78.00 $142.00 | 23 | |
Itraconazole, though primarily an antifungal, has been shown to inhibit SMO, indirectly impacting HHIP. | ||||||
Robotnikinin | 1132653-79-2 | sc-396554 | 1 mg | $650.00 | 1 | |
Robotnikinin disrupts SHH-induced activation of the hedgehog pathway, potentially impacting HHIP indirectly. | ||||||
PF-5274857 | 1373615-35-0 | sc-478208 | 5 mg | $360.00 | ||
PF-5274857 selectively inhibits SMO, which plays a crucial role in hedgehog signaling, thus affecting HHIP. | ||||||
SANT-1 | 304909-07-7 | sc-203253 | 5 mg | $135.00 | 5 | |
SANT1 selectively inhibits SMO and could indirectly modulate HHIP through its role in hedgehog signaling. | ||||||