Herc3 Activators
increase of cAMP, activates PKA which can lead to the phosphorylation and activation of Herc3, thus boosting its E3 ubiquitin ligase activity. This is complemented by Epigallocatechin Gallate's inhibition of competing protein kinases, streamlining the activation process for Herc3. Ionomycin and A23187, both calcium ionophores, enhance Herc3 by elevating intracellular calcium and activating calcium-dependent kinases that may target Herc3 for activation. PMA, a potent activator of PKC, can phosphorylate proteins that interact with Herc3, potentially enhancing its ligase activity, while LY294002 and U0126, as PI3K and MEK inhibitors respectively, may influence Herc3's activity by modulating its phosphorylation state or that of its substrates.
Further modulation of Herc3 activity is observed with SB203580, a p38 MAPK inhibitor, which may indirectly enhance Herc3 by shifting substrate availability, and Sphingosine-1-phosphate, which can initiate G-protein coupled receptor signaling with downstream effects on Herc3 activation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate Herc3, enhancing its E3 ubiquitin ligase activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate (EGCG) inhibits several protein kinases, potentially reducing competition for substrates or co-factors required for Herc3's ubiquitination activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin acts as a calcium ionophore, raising intracellular calcium levels. This can activate calcium/calmodulin-dependent protein kinases that may phosphorylate Herc3, increasing its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can lead to the phosphorylation of substrates that interact with Herc3, potentially enhancing its E3 ligase function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter signaling pathways leading to changes in Herc3 phosphorylation status or protein-protein interactions, enhancing its ubiquitin ligase activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that could shift signaling dynamics, possibly resulting in enhanced Herc3 activity due to altered substrate availability or phosphorylation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 acts as a calcium ionophore, similar to Ionomycin, and could enhance Herc3 activity by affecting calcium-dependent phosphorylation pathways. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
This lipid signaling molecule can activate G-protein coupled receptors, leading to downstream effects that may include the post-translational modification of Herc3, enhancing its activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that can increase the levels of ubiquitinated proteins, potentially enhancing the recognition and activity of Herc3 on its substrates. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is an inhibitor of protein phosphatases PP1 and PP2A, which may lead to increased phosphorylation levels of Herc3 or its associated proteins, enhancing its ubiquitin ligase activity. | ||||||