Herc3 Antibody (37.2): sc-100720

Herc3 Antibody (37.2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Herc3 protein of human origin by immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Herc3 antibody (37.2) is available as a non-conjugated monoclonal isotype antibody. Herc3, also known as HECT domain and RCC1-like domain-containing protein 3, is a 1,050 amino acid protein that plays a crucial role in cellular protein degradation pathways. Herc3 functions as an E3 ubiquitin ligase, facilitating the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to target proteins destined for degradation. This process is vital for maintaining cellular homeostasis and regulating various biological processes, including cell cycle progression and response to stress. Herc3 is primarily localized in the cytoplasm and vesicular-like structures, which is significant as Herc3 can interact with substrates that are also present in these cellular compartments. Additionally, Herc3 contains one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and seven RCC1 repeats, which are essential for E3 ubiquitin ligase activity. Following ubiquitination, Herc3 is marked for proteasomal degradation, highlighting the dynamic regulation of this protein within the cell.

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Herc3 Antibody (37.2) References:

1. Assignment of the human P532 gene (HERC1) to chromosome 15q22 by fluorescence in situ hybridization.  |  Cruz, C., et al. 1999. Cytogenet Cell Genet. 86: 68-9. PMID: 10516438
2. The human HERC3 gene maps to chromosome 4q21 by fluorescence in situ hybridization.  |  Cruz, C., et al. 1999. Cytogenet Cell Genet. 87: 263-4. PMID: 10702688
3. The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects.  |  Hochrainer, K., et al. 2005. Genomics. 85: 153-64. PMID: 15676274
4. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.  |  Nomura, N., et al. 1994. DNA Res. 1: 27-35. PMID: 7584026

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Herc3 Antibody (37.2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Herc3 Antibody (37.2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Herc3 Antibody (37.2) Specifications

Alternate Product Name: Herc3

Product Clone Name: 37.2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-110

Epitope Target: Herc3

Epitope Species: human

Product Reactivity/Detection: Herc3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Herc3 Antibody (37.2): N/A