HepaCAM inhibitors belong to a class of chemical compounds designed to target and modulate the activity of the HepaCAM protein, also known as Hepatocellular Carcinoma-Associated Antigen 2. HepaCAM is a transmembrane protein that has been implicated in various cellular processes, although its precise functions are still being elucidated. It was initially identified as a marker for hepatocellular carcinoma, a type of liver cancer, but subsequent research has suggested broader roles in cellular adhesion, migration, and neuronal processes. Inhibitors designed to target HepaCAM are primarily employed in molecular and cellular biology research to investigate the functional properties and regulatory mechanisms associated with this protein.
The development of HepaCAM inhibitors typically involves a combination of biochemical, biophysical, and structural approaches aimed at identifying or designing molecules that can selectively interact with HepaCAM and modulate its activity within cells. By inhibiting HepaCAM, these compounds can disrupt its roles in cellular adhesion, migration, or other processes, depending on the context. Researchers use HepaCAM inhibitors to explore the intricate roles played by this protein in cellular functions, attempting to unravel its contributions to cancer biology, neuronal development, or other processes where HepaCAM may be involved. Furthermore, these inhibitors serve as valuable tools for dissecting the broader network of cellular pathways involving HepaCAM, contributing to our understanding of fundamental cell biology mechanisms and providing insights into avenues for further scientific exploration.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, might indirectly reduce HepaCAM expression by altering methylation patterns of DNA. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat, an HDAC inhibitor, may indirectly decrease HepaCAM expression by changing the chromatin structure and gene expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine is another DNA methyltransferase inhibitor, which could potentially lower HepaCAM expression through DNA demethylation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to modulate multiple signaling pathways, possibly affecting the transcriptional regulation of HepaCAM. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, may downregulate HepaCAM expression by disrupting cell signaling pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can modulate various transcription factors, potentially leading to altered HepaCAM expression. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide is known for its broad effects on transcription, which might include decreasing HepaCAM expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Sirolimus inhibits mTOR signaling and could indirectly reduce HepaCAM expression through this pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
As a PI3K inhibitor, LY294002 might downregulate HepaCAM expression by affecting downstream signaling. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
WZB117 inhibits glucose transporter 1 (GLUT1), which might indirectly influence HepaCAM expression due to altered metabolic states. | ||||||