HepaCAM Antibody (B-7): sc-515637

HepaCAM Antibody (B-7) is a mouse monoclonal IgM kappa antibody that detects HepaCAM protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-HepaCAM antibody (B-7) is available as the non-conjugated form. HepaCAM, also known as hepatocyte cell adhesion molecule or GlialCAM, is a 416 amino acid single-pass type I membrane protein characterized by one immunoglobulin-like C2-type domain and one immunoglobulin-like V-type domain. HepaCAM (B-7) antibody targets a protein primarily localized to the cytoplasmic side of the membrane, where HepaCAM functions as a homodimer, playing a critical role in regulating cell-matrix interactions and cell motility. HepaCAM′s importance extends to involvement in suppressing cellular proliferation, suggesting a significant role in cell growth inhibition and tumor suppression, particularly in hepatocellular carcinoma. The cytoplasmic domain of HepaCAM is essential for maintaining cell-matrix adhesion; deletion of this domain leads to reduced adhesion capabilities, highlighting HepaCAM′s crucial function in cellular integrity. HepaCAM exists in two isoforms due to alternative splicing, which may contribute to diverse functional roles in various cellular contexts.

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HepaCAM Antibody (B-7) References:

1. HEPN1, a novel gene that is frequently down-regulated in hepatocellular carcinoma, suppresses cell growth and induces apoptosis in HepG2 cells.  |  Moh, MC., et al. 2003. J Hepatol. 39: 580-6. PMID: 12971969
2. Cloning and characterization of hepaCAM, a novel Ig-like cell adhesion molecule suppressed in human hepatocellular carcinoma.  |  Chung Moh, M., et al. 2005. J Hepatol. 42: 833-41. PMID: 15885354
3. Structural and functional analyses of a novel ig-like cell adhesion molecule, hepaCAM, in the human breast carcinoma MCF7 cells.  |  Moh, MC., et al. 2005. J Biol Chem. 280: 27366-74. PMID: 15917256
4. Purification of the extracellular domain of the membrane protein GlialCAM expressed in HEK and CHO cells and comparison of the glycosylation.  |  Gaudry, JP., et al. 2008. Protein Expr Purif. 58: 94-102. PMID: 18082421
5. GlialCAM, an immunoglobulin-like cell adhesion molecule is expressed in glial cells of the central nervous system.  |  Favre-Kontula, L., et al. 2008. Glia. 56: 633-45. PMID: 18293412
6. Expression of hepaCAM is downregulated in cancers and induces senescence-like growth arrest via a p53/p21-dependent pathway in human breast cancer cells.  |  Moh, MC., et al. 2008. Carcinogenesis. 29: 2298-305. PMID: 18845560

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HepaCAM Antibody (B-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-HepaCAM Antibody (B-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HepaCAM Antibody (B-7) Specifications

Alternate Product Name: HepaCAM

Product Clone Name: B-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 81-102

Epitope Target: HepaCAM

Epitope Species: human

Product Reactivity/Detection: HepaCAM

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HepaCAM Antibody (B-7): P: Blocking Peptide