HELZ Inhibitors
HELZ inhibitors like Seliciclib and MG132 target the cell cycle and proteasomal degradation, respectively, leading to altered protein stability and abundance which can have downstream effects on protein function and cell regulatory mechanisms. DNA and histone modification inhibitors such as 5-Azacytidine and Vorinostat can lead to changes in gene expression by altering epigenetic marks, which can result in modified protein synthesis. Their impact is broad, influencing numerous proteins and cellular pathways. Kinase inhibitors, including LY294002, Epigallocatechin gallate, and SP600125, disrupt key regulatory pathways that can lead to changes in the activity and levels of many proteins. Specifically, LY294002 and SP600125 target the PI3K/Akt and JNK pathways, respectively, which are crucial for cell survival and apoptosis.
Rapamycin, an mTOR inhibitor, specifically suppresses the mTORC1 complex, resulting in decreased protein synthesis and impacting proteins involved in growth and metabolism. Bortezomib, another proteasome inhibitor like MG132, prevents the breakdown of proteins, thereby affecting proteins that regulate the cell cycle and apoptosis. Nutlin-3, by antagonizing MDM2, indirectly stabilizes and activates p53, influencing proteins within the p53 pathway which is central to the cellular response to stress and DNA damage.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Inhibits transcription by affecting polymerase activity, can reduce protein expression. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Cyclin-dependent kinase inhibitor, can disrupt cell cycle progression and transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor, can alter gene expression patterns and protein production. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor, can lead to increased levels of proteins targeted for degradation, affecting various signaling pathways. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Binds to DNA and inhibits RNA polymerase, can affect transcription and protein synthesis. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor, can disrupt Akt signaling affecting protein translation and cell survival. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor, can suppress protein synthesis by inhibiting mTORC1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A broad inhibitor of several kinases, can affect multiple signaling pathways and protein activities. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
A proteasome inhibitor, can prevent the degradation of proteins involved in cell cycle regulation and apoptosis. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
A histone deacetylase inhibitor, can change expression levels of various proteins by altering chromatin structure. | ||||||