HELZ Antibody (FA-52): sc-130438
- HELZ Antibody (FA-52) is a mouse monoclonal IgG2b κ HELZ antibody provided at 100 µg/ml
- raised against recombinant HELZ of human origin
- recommended for detection of HELZ of human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HELZ Antibody (FA-52). This work is in progress.
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HELZ Antibody (FA-52) is a mouse monoclonal IgG2b kappa light chain antibody that detects HELZ protein of human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-HELZ antibody (FA-52) is available as the non-conjugated form. HELZ, also known as helicase with zinc finger, DHRC, or HUMORF5, is a crucial nuclear protein composed of 1,942 amino acids and features a C3H1-type zinc finger, placing HELZ within the RNA helicase superfamily. HELZ is expressed ubiquitously during embryonic development and plays a vital role in modifying RNA structure, which is essential for proper development of multiple organs and tissues in the embryo. By unwinding double-stranded RNA regions, HELZ alters RNA conformation, thereby influencing biological activity and ensuring correct genetic information is accessible for translation and other cellular processes. HELZ′s ability to interact with various RNA molecules highlights HELZ′s importance in gene regulation and cellular function, making HELZ a significant target for research in developmental biology and related fields.
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HELZ Antibody (FA-52) References:
- Identification of a differentially expressed RNA helicase by gene trapping. | Wagner, DS., et al. 1999. Biochem Biophys Res Commun. 262: 677-84. PMID: 10471385
- Down-regulation in human cancers of DRHC, a novel helicase-like gene from 17q25.1 that inhibits cell growth. | Nagai, H., et al. 2003. Cancer Lett. 193: 41-7. PMID: 12691822
- SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. | Hamamoto, R., et al. 2004. Nat Cell Biol. 6: 731-40. PMID: 15235609
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. | Suzuki, Y., et al. 2004. Genome Res. 14: 1711-8. PMID: 15342556
- Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. | Nomura, N., et al. 1994. DNA Res. 1: 223-9. PMID: 7584044
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HELZ Antibody (FA-52) | sc-130438 | 100 µg/ml | $339.00 |