Date published: 2025-10-10

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HDAC10 Activators

HDAC10, a member of the histone deacetylase (HDAC) family, is a multifunctional protein involved in various cellular processes. Its primary function revolves around histone deacetylation, where it catalyzes the removal of acetyl groups from lysine residues on histone proteins, thereby regulating chromatin structure and gene expression. Beyond histone deacetylation, HDAC10 interacts with non-histone proteins, implicating its involvement in diverse cellular pathways such as cell cycle progression, DNA repair, and cellular differentiation. Through these interactions, HDAC10 plays a pivotal role in maintaining cellular homeostasis and coordinating essential biological functions. Activation of HDAC10 involves intricate mechanisms that regulate its enzymatic activity and functional relevance within cellular contexts. Various signaling pathways and post-translational modifications govern HDAC10 activation. For instance, phosphorylation events mediated by kinases such as protein kinase A (PKA) and protein kinase C (PKC) have been implicated in activating HDAC10. Additionally, interactions with cofactors and other regulatory proteins modulate HDAC10 activity. Furthermore, cellular stimuli and environmental cues can trigger signaling cascades that culminate in the activation of HDAC10, allowing for dynamic regulation of its functions in response to physiological demands. Understanding the intricacies of HDAC10 activation pathways provides insights into its physiological roles and sheds light on strategies for modulating its activity in cellular contexts.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Honokiol

35354-74-6sc-202653
sc-202653A
10 mg
25 mg
$118.00
$178.00
4
(1)

Potential HDAC10 activator through modulation of intracellular signaling pathways. Honokiol has been reported to influence pathways related to cell survival and apoptosis, indirectly affecting HDAC10 activity and potentially promoting its activation.

M 344

251456-60-7sc-203124
sc-203124A
1 mg
5 mg
$107.00
$316.00
8
(1)

Broad-spectrum HDAC inhibitor with potential indirect activation of HDAC10. M344's influence on histone acetylation patterns may lead to altered chromatin dynamics, impacting gene expression patterns associated with HDAC10 function.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

Polyphenolic compound with reported indirect effects on HDAC activity. Resveratrol can influence signaling pathways related to cellular stress and metabolism, potentially indirectly activating HDAC10 through modulation of shared pathways.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Polyphenolic compound with reported modulation of HDAC activity. Curcumin's impact on various cellular processes, including inflammation and oxidative stress, may indirectly influence HDAC10 activity, potentially leading to its activation.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$30.00
$46.00
$82.00
$218.00
19
(3)

Short-chain fatty acid with reported HDAC inhibitory effects. Despite being an inhibitor, low concentrations of sodium butyrate may paradoxically activate HDAC10 by modulating acetylation levels and downstream signaling pathways, influencing its activation state.

Nicotinamide

98-92-0sc-208096
sc-208096A
sc-208096B
sc-208096C
100 g
250 g
1 kg
5 kg
$43.00
$65.00
$200.00
$815.00
6
(1)

NAD+ precursor that may indirectly influence HDAC10 through modulation of cellular energy metabolism. By impacting NAD+ levels, Nicotinamide can influence sirtuin-mediated deacetylation, potentially indirectly activating HDAC10 through shared pathways.

Panobinostat

404950-80-7sc-208148
10 mg
$196.00
9
(1)

Broad-spectrum HDAC inhibitor with potential indirect effects on HDAC10. Panobinostat's impact on chromatin dynamics and gene expression patterns may lead to altered cellular processes, indirectly affecting HDAC10 and potentially promoting its activation.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$108.00
$245.00
$918.00
$49.00
33
(2)

Flavonoid with reported HDAC inhibitory effects. Similar to sodium butyrate, low concentrations of Quercetin may paradoxically activate HDAC10 through modulation of acetylation levels and downstream signaling pathways, influencing its activation state.

Suberoylanilide Hydroxamic Acid

149647-78-9sc-220139
sc-220139A
100 mg
500 mg
$130.00
$270.00
37
(2)

Broad-spectrum HDAC inhibitor with potential indirect effects on HDAC10. Vorinostat's impact on chromatin dynamics and gene expression patterns may lead to altered cellular processes, indirectly affecting HDAC10 and potentially promoting its activation.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

Broad-spectrum HDAC inhibitor with potential indirect effects on HDAC10. Trichostatin A's influence on histone acetylation patterns may lead to altered chromatin dynamics, impacting gene expression patterns associated with HDAC10 function.