Molecular structure of M 344, CAS Number: 251456-60-7
M 344 (CAS 251456-60-7)
See product citations (8)
Application:
M 344 is a potent HDAC inhibitor with IC50 of 100 nM
CAS Number:
251456-60-7
Purity:
≥98%
Molecular Weight:
307.39
Molecular Formula:
C16H25N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
M 344 is a potent HDAC inhibitor (IC50 = 100 nM), with selectivity for HDAC6 over HDAC1. It induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. It also induces cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells. In addition, M 344 is used in the study of enzyme kinetics, metabolism, protein-ligand interactions, and cell signaling pathways.
M 344 (CAS 251456-60-7) References
- Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. | Jung, M., et al. 1999. J Med Chem. 42: 4669-79. PMID: 10579829
- Strategies of chemoprevention based on antigenic and molecular markers of early and premalignant lesions of the bladder. | Fradet, Y., et al. 1992. J Cell Biochem Suppl. 16I: 85-92. PMID: 1305695
- The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells. | Riessland, M., et al. 2006. Hum Genet. 120: 101-10. PMID: 16724231
- Histone Deacetylase Inhibitor M344 Inhibits Cell Proliferation and Induces Apoptosis in Human THP-1 Leukemia Cells. | Li, X. and Chen, BD. 2009. Am J Biomed Sci. 1: 352-363. PMID: 20526416
- Activating Transcription Factor 3 regulates in part the enhanced tumour cell cytotoxicity of the histone deacetylase inhibitor M344 and cisplatin in combination. | St Germain, C., et al. 2010. Cancer Cell Int. 10: 32. PMID: 20828393
- The effect of the histone deacetylase inhibitor M344 on BRCA1 expression in breast and ovarian cancer cells. | Weberpals, JI., et al. 2011. Cancer Cell Int. 11: 29. PMID: 21854619
- HDAC inhibitor M344 suppresses MCF-7 breast cancer cell proliferation. | Yeung, A., et al. 2012. Biomed Pharmacother. 66: 232-6. PMID: 22436652
- Histone deacetylase inhibitor M344 significantly improves nuclear reprogramming, blastocyst quality, and in vitro developmental capacity of cloned pig embryos. | Jin, L., et al. 2017. J Anim Sci. 95: 1388-1395. PMID: 28380503
- M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory. | Volmar, CH., et al. 2017. Proc Natl Acad Sci U S A. 114: E9135-E9144. PMID: 29073110
- Pan-HDAC Inhibitors Promote Tau Aggregation by Increasing the Level of Acetylated Tau. | Jeong, H., et al. 2019. Int J Mol Sci. 20: PMID: 31480543
- The histone deacetylase inhibitor M344 as a multifaceted therapy for pancreatic cancer. | Knoche, SM., et al. 2022. PLoS One. 17: e0273518. PMID: 36126055
- Increased recombinant adeno-associated virus production by HEK293 cells using small molecule chemical additives. | Scarrott, JM., et al. 2023. Biotechnol J. 18: e2200450. PMID: 36495042
- Enhanced detection of bladder cancer in urine cytology with Lewis X, M344 and 19A211 antigens. | Sagerman, PM., et al. 1994. Acta Cytol. 38: 517-23. PMID: 7913791
- Tumor-associated antigens as prognostic factors for recurrence in 382 patients with primary transitional cell carcinoma of the bladder. | Allard, P., et al. 1995. Clin Cancer Res. 1: 1195-202. PMID: 9815912
Inhibitor of:
ACTR6, ASCL5, CHRAC17, DNHD1, G3BP1, HDAC1, HDAC6, HEF1, HIRA, Histone H3.3A, ING5, INO80C, kismet, Mesogenin 1, MSL3L2, Msx-3, Rub1, SET8, Sp9, SRPK3, Subh2bv, VPS72, ZNF607, ZNF740, and ZNHIT1.Activator of:
Glrp-1, Histone cluster 1 H3D, Histone cluster 1 H4G, Histone cluster 2 H2AC, Histone cluster 2 H3C1, HMG-14, Morc1, MRG15, NAP1L2, NAP1L5, RTF1, SMC3, TADA3L, TESSP5, ZBBX_FLJ23049, ZMYND12, ZNF21, ZNF396, ZNF709, and ZSWIM6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
M 344, 1 mg | sc-203124 | 1 mg | $107.00 | |||
M 344, 5 mg | sc-203124A | 5 mg | $316.00 |