HAPLN1 Inhibitors
Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1) inhibitors belong to a distinctive chemical class that primarily targets the modulation of the HAPLN1 protein. HAPLN1 is a crucial extracellular matrix protein involved in mediating interactions between hyaluronan (HA) and proteoglycans, contributing to the structural integrity and stability of various tissues. The inhibitors designed to counteract HAPLN1 activity aim to interfere with the binding of HAPLN1 to its molecular counterparts, thereby disrupting the formation of stable complexes within the extracellular matrix.
HAPLN1 inhibitors typically exhibit a specific structural configuration that allows them to interact selectively with the active sites or binding domains of HAPLN1. By doing so, these inhibitors impede the natural functions of HAPLN1 in organizing and stabilizing the extracellular matrix. The inhibition of HAPLN1 can have profound effects on cellular processes, influencing cell adhesion, migration, and tissue development.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
4-Methylumbelliferone | 90-33-5 | sc-206910 sc-206910A sc-206910B sc-206910C sc-206910D | 25 g 100 g 250 g 1 kg 2.5 kg | $34.00 $55.00 $138.00 $423.00 $954.00 | 2 | |
Inhibits hyaluronan synthesis by suppressing the expression of hyaluronan synthase. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Inhibits protein tyrosine kinases which can affect cellular pathways involving HAPLN1. | ||||||
D-Glucosamine | 3416-24-8 | sc-278917A sc-278917 | 1 g 10 g | $197.00 $764.00 | ||
Can alter the synthesis of proteoglycans and therefore modify the interactions with HAPLN1. | ||||||
2-Hydroxypropyl-β-cyclodextrin | 128446-35-5 | sc-203461 sc-203461B sc-203461C sc-203461A | 1 g 100 g 500 g 5 g | $52.00 $620.00 $1950.00 $130.00 | 8 | |
Can disrupt lipid rafts, potentially affecting HAPLN1-related signaling pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor that can affect cell signaling pathways involving HAPLN1. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor that can affect cell signaling pathways involving HAPLN1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAP kinase inhibitor that can influence signaling pathways in which HAPLN1 is involved. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor that can affect cell signaling pathways involving HAPLN1. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $70.00 $290.00 $600.00 | 19 | |
Inhibits NF-kB signaling which can affect the expression of genes related to HAPLN1 function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Acts on multiple signaling pathways and can modify the expression of matrix-related genes. | ||||||