Hairless Inhibitors
Hairless inhibitors primarily operate by blocking or dampening pathways that either directly or indirectly interact with Hairless, particularly the Notch and Wnt/β-catenin pathways. For example, IWR-1 inhibits the Wnt/β-catenin pathway by stabilizing Axin, which leads to reduced Notch signaling, a pathway where Hairless serves as a transcriptional corepressor. Another compound, DAPT, is a γ-secretase inhibitor that directly blocks the release of NICD, an essential cofactor for Hairless in Notch repression. Similarly, MG132, a proteasome inhibitor, the degradation of Hairless, ensuring that it is available in sufficient quantities to participate in the repression of Notch signaling.
Inhibitors like LY294002 and Rapamycin affect other cellular pathways that have indirect consequences on Hairless function. LY294002, a PI3K inhibitor, impacts Hairless by reducing Akt phosphorylation, leading to increased GSK-3β activity which may result in Hairless degradation. On the other hand, Rapamycin, an mTOR inhibitor, has a broad effect on protein translation and thus can limit the availability of Hairless for Notch repression. Taken together, these inhibitors offer a multi-faceted approach to modulating Hairless function by targeting a range of biochemical pathways and interactions.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $132.00 | 19 | |
Inhibits Wnt/β-catenin pathway by stabilizing Axin, thereby reducing the activation of Notch signaling that is needed for Hairless functionality. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
γ-Secretase inhibitor which blocks Notch intracellular domain (NICD) release, a cofactor for Hairless in repression of Notch signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor that reduces Akt phosphorylation, thus promoting GSK-3β activity which may lead to Hairless degradation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Inhibits p38 MAPK, preventing phosphorylation events that could activate RBP-J, a factor interacting with Hairless in Notch signaling. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Proteasome inhibitor that can prevent Hairless degradation, thereby increasing its availability for Notch repression. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
Tankyrase inhibitor, stabilizes Axin which is a negative regulator of the Wnt pathway, subsequently limiting Hairless activity in Notch signaling. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
CaMKII inhibitor which affects calcium signaling, thereby influencing Hairless-mediated transcriptional repression in Notch signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor which can affect protein translation including that of Hairless, affecting its availability for Notch signaling repression. | ||||||
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $210.00 $320.00 $1250.00 | 1 | |
Porcupine inhibitor that hampers Wnt secretion, and consequently limits the activation of the Notch pathway where Hairless acts. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor which can prevent AP-1 activation, a factor that may collaborate with Hairless in Notch signaling. | ||||||