H2-Q8 inhibitors constitute a specific class of chemical compounds designed to modulate the activity of the H2-Q8 protein. H2-Q8, also known as histocompatibility 2, Q region locus 8, is a protein component of the major histocompatibility complex (MHC) system, particularly in mice. The MHC system plays a pivotal role in the immune response, serving as a key player in presenting antigenic peptides to T cells. This essential process enables the immune system to recognize and mount responses against foreign pathogens. H2-Q8, much like other MHC molecules, is intricately involved in the process of antigen presentation, a fundamental mechanism that allows the body to initiate immune responses against infections. The development of H2-Q8 inhibitors is primarily driven by the goal of selectively interacting with the H2-Q8 protein, potentially influencing its antigen-presenting activity and impacting immune recognition processes.
Typically, H2-Q8 inhibitors are composed of small molecules or chemical compounds that are specifically engineered to bind to H2-Q8, targeting either its active site or allosteric sites. This interaction has the potential to modify H2-Q8's behavior, potentially affecting its ability to present antigenic peptides to T cells and, consequently, influencing the immune response against foreign antigens. Researchers are dedicated to unraveling the molecular mechanisms and functions of H2-Q8 within the MHC system, aiming to gain insights into the complex immune recognition processes. The development of H2-Q8 inhibitors represents an ongoing and dynamic area of research within the fields of immunology and molecular pharmacology, contributing to a deeper understanding of the immune system's functioning and its role in detecting and responding to foreign antigens.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Disrupts protein transport by inhibiting the exchange of protein carrier molecules, possibly decreasing MHC class I expression. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Inhibits N-linked glycosylation, potentially reducing the stability and expression of glycoproteins like MHC molecules. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Disrupts Golgi apparatus function, which is necessary for MHC class I molecule maturation and surface expression. | ||||||
Castanospermine | 79831-76-8 | sc-201358 sc-201358A | 100 mg 500 mg | $180.00 $620.00 | 10 | |
Inhibits glycosidase enzymes, affecting glycoprotein processing and potentially MHC class I molecule expression. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Disrupts microtubule polymerization, which can interfere with intracellular transport and expression of membrane proteins. | ||||||
Deoxynojirimycin | 19130-96-2 | sc-201369 sc-201369A | 1 mg 5 mg | $72.00 $142.00 | ||
Inhibits glycosidase enzymes, potentially altering the glycosylation and expression of membrane proteins like MHC molecules. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $158.00 $306.00 $1186.00 | 9 | |
Inhibits fatty acid synthase, which could affect lipid rafts and, consequently, the membrane organization of MHC class I molecules. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Inhibits V-ATPases, affecting acidification of organelles such as endosomes and lysosomes, which can influence antigen processing. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Inhibits proteasome activity, potentially affecting the degradation of proteins including those involved in MHC class I expression. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $173.00 $612.00 | 3 | |
Inhibitor of the sarcoplasmic-endoplasmic reticulum Ca2+ ATPase (SERCA), affecting calcium homeostasis and protein trafficking. | ||||||