Date published: 2025-10-30

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H2-Q8 Inhibitors

H2-Q8 inhibitors constitute a specific class of chemical compounds designed to modulate the activity of the H2-Q8 protein. H2-Q8, also known as histocompatibility 2, Q region locus 8, is a protein component of the major histocompatibility complex (MHC) system, particularly in mice. The MHC system plays a pivotal role in the immune response, serving as a key player in presenting antigenic peptides to T cells. This essential process enables the immune system to recognize and mount responses against foreign pathogens. H2-Q8, much like other MHC molecules, is intricately involved in the process of antigen presentation, a fundamental mechanism that allows the body to initiate immune responses against infections. The development of H2-Q8 inhibitors is primarily driven by the goal of selectively interacting with the H2-Q8 protein, potentially influencing its antigen-presenting activity and impacting immune recognition processes.

Typically, H2-Q8 inhibitors are composed of small molecules or chemical compounds that are specifically engineered to bind to H2-Q8, targeting either its active site or allosteric sites. This interaction has the potential to modify H2-Q8's behavior, potentially affecting its ability to present antigenic peptides to T cells and, consequently, influencing the immune response against foreign antigens. Researchers are dedicated to unraveling the molecular mechanisms and functions of H2-Q8 within the MHC system, aiming to gain insights into the complex immune recognition processes. The development of H2-Q8 inhibitors represents an ongoing and dynamic area of research within the fields of immunology and molecular pharmacology, contributing to a deeper understanding of the immune system's functioning and its role in detecting and responding to foreign antigens.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Brefeldin A

20350-15-6sc-200861C
sc-200861
sc-200861A
sc-200861B
1 mg
5 mg
25 mg
100 mg
$30.00
$52.00
$122.00
$367.00
25
(3)

Disrupts protein transport by inhibiting the exchange of protein carrier molecules, possibly decreasing MHC class I expression.

Tunicamycin

11089-65-9sc-3506A
sc-3506
5 mg
10 mg
$169.00
$299.00
66
(3)

Inhibits N-linked glycosylation, potentially reducing the stability and expression of glycoproteins like MHC molecules.

Monensin A

17090-79-8sc-362032
sc-362032A
5 mg
25 mg
$152.00
$515.00
(1)

Disrupts Golgi apparatus function, which is necessary for MHC class I molecule maturation and surface expression.

Castanospermine

79831-76-8sc-201358
sc-201358A
100 mg
500 mg
$180.00
$620.00
10
(1)

Inhibits glycosidase enzymes, affecting glycoprotein processing and potentially MHC class I molecule expression.

Colchicine

64-86-8sc-203005
sc-203005A
sc-203005B
sc-203005C
sc-203005D
sc-203005E
1 g
5 g
50 g
100 g
500 g
1 kg
$98.00
$315.00
$2244.00
$4396.00
$17850.00
$34068.00
3
(2)

Disrupts microtubule polymerization, which can interfere with intracellular transport and expression of membrane proteins.

Deoxynojirimycin

19130-96-2sc-201369
sc-201369A
1 mg
5 mg
$72.00
$142.00
(0)

Inhibits glycosidase enzymes, potentially altering the glycosylation and expression of membrane proteins like MHC molecules.

Cerulenin (synthetic)

17397-89-6sc-200827
sc-200827A
sc-200827B
5 mg
10 mg
50 mg
$158.00
$306.00
$1186.00
9
(1)

Inhibits fatty acid synthase, which could affect lipid rafts and, consequently, the membrane organization of MHC class I molecules.

Bafilomycin A1

88899-55-2sc-201550
sc-201550A
sc-201550B
sc-201550C
100 µg
1 mg
5 mg
10 mg
$96.00
$250.00
$750.00
$1428.00
280
(6)

Inhibits V-ATPases, affecting acidification of organelles such as endosomes and lysosomes, which can influence antigen processing.

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$56.00
$260.00
$980.00
163
(3)

Inhibits proteasome activity, potentially affecting the degradation of proteins including those involved in MHC class I expression.

Cyclopiazonic Acid

18172-33-3sc-201510
sc-201510A
10 mg
50 mg
$173.00
$612.00
3
(1)

Inhibitor of the sarcoplasmic-endoplasmic reticulum Ca2+ ATPase (SERCA), affecting calcium homeostasis and protein trafficking.