H2-Kb Inhibitors
H2-Kb inhibitors are chemical compounds that target the murine MHC class I molecule, specifically the H2-Kb allele. These inhibitors interfere with the interaction between H2-Kb molecules and peptides, affecting the process by which antigenic peptides are presented to CD8+ T cells. The H2-Kb molecule is integral to the immune system's ability to recognize and respond to intracellular pathogens, as it binds endogenous peptides, including those derived from viruses or other pathogens, and presents them on the cell surface for recognition by T cell receptors (TCRs). Inhibiting the binding or function of H2-Kb can modulate antigen presentation, thus altering the immune system's recognition of cellular events. This class of inhibitors may block peptide loading, prevent the stabilization of the MHC-peptide complex, or otherwise interfere with the conformational stability of the H2-Kb molecules.
Structurally, H2-Kb inhibitors may vary widely, but their common goal is to disrupt the peptide-binding groove of the H2-Kb molecule or affect the interaction between the MHC complex and other immune co-factors. This disruption can occur at different stages of the peptide loading process, such as during peptide selection and binding within the endoplasmic reticulum or later as the H2-Kb-peptide complex is trafficked to the cell surface. The chemical diversity of these inhibitors reflects the variety of mechanisms through which the H2-Kb presentation pathway can be modulated. Understanding the precise interactions between these inhibitors and the H2-Kb structure is critical for elucidating how they affect MHC-I-related cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A promotes histone acetylation, potentially leading to a condensed chromatin state around the H2-Kb gene locus, which could result in reduced transcription efficiency. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to suppress NF-κB pathway activation, which might lead to the downregulation of H2-Kb expression due to the pivotal role of NF-κB in immune gene transcription. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate's inhibition of histone deacetylases can cause hyperacetylation, potentially silencing the H2-Kb gene and leading to a decrease in the protein's cellular levels. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine disrupts lysosomal acidification, which may result in the improper assembly of H2-Kb molecules with their antigenic peptides, subsequently reducing their surface expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol might decrease the expression of H2-Kb by altering the activity of specific transcription factors responsible for the gene's transcriptional activity. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin blocks N-linked glycosylation, potentially leading to a build-up of misfolded H2-Kb proteins that are then targeted for degradation rather than presented on the cell surface. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 could lead to the accumulation of cellular proteins that negatively control H2-Kb gene transcription, thus reducing its expression. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib might decrease the degradation of proteins that negatively regulate H2-Kb transcription, resulting in a lower level of H2-Kb expression. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide can induce DNA damage responses that might arrest the cell cycle, thereby potentially inhibiting the transcription machinery necessary for H2-Kb expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A can bind to specific DNA sequences, potentially inhibiting the binding of transcription factors to the H2-Kb promoter region and decreasing its expression. | ||||||