H2-Ab Inhibitors
H2-Ab inhibitors are a specialized class of chemical compounds that target the H2-Ab gene product, which is part of the murine major histocompatibility complex (MHC) class II system. The H2-Ab molecule is critical for the presentation of extracellular peptides to CD4+ T cells, a process that initiates specific immune responses. As part of the MHC class II family, H2-Ab is composed of an alpha chain that pairs with a beta chain, forming a heterodimer. This heterodimer binds peptides and displays them on the surface of antigen-presenting cells for recognition by T cells. H2-Ab inhibitors function by disrupting these molecular interactions, either by inhibiting peptide binding, destabilizing the protein structure, or blocking its ability to reach the cell surface where peptide presentation occurs.
These inhibitors can work through various mechanisms, such as binding directly to the peptide-binding cleft of the H2-Ab molecule or preventing the assembly of the alpha and beta chains. By blocking these processes, H2-Ab inhibitors prevent the normal recognition and interaction between the antigen-presenting cells and T cells. Given the highly specific nature of MHC molecules, inhibitors are typically designed to interact selectively with the H2-Ab variant, which is unique to mice. The study of H2-Ab inhibitors is particularly important in immunological research models, as it helps to reveal intricate details of antigen presentation and immune system regulation in murine systems. This knowledge can contribute to a deeper understanding of how molecular interactions in antigen presentation influence immune signaling and response.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may downregulate H2-Ab by impeding histone deacetylase activity, leading to chromatin condensation near the gene's promoter and a subsequent decrease in transcription levels. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This chemical could decrease H2-Ab expression by obstructing DNA methyltransferase, thereby disrupting the methylation status of the gene's promoter and attenuating the binding affinity of transcription factors. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
By binding to GC-rich DNA sequences, Mithramycin A may specifically inhibit the initiation of transcription of the H2-Ab gene, culminating in a reduction of its mRNA and protein levels. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine may indirectly suppress H2-Ab expression by increasing the pH within endosomes and lysosomes, impairing the antigen processing that is essential for MHC class II molecule function, including H2-Ab. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin could downregulate H2-Ab by restraining specific kinases involved in the activation of transcription factors necessary for the gene's expression, resulting in decreased H2-Ab mRNA synthesis. | ||||||
Wogonin, S. baicalensis | 632-85-9 | sc-203313 | 10 mg | $200.00 | 8 | |
By attenuating the expression of co-stimulatory molecules and cytokines necessary for optimal MHC class II expression, Wogonin might specifically target pathways that lead to a reduction in H2-Ab levels. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate might repress H2-Ab by altering the expression of enzymes that control histone modification, leading to a repressive chromatin state around the H2-Ab gene locus. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
This compound could inhibit the activation of the NF-κB pathway, a critical controller of H2-Ab transcription, thereby directly leading to diminished expression of the H2-Ab gene. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may directly interfere with the signaling pathways such as MAPK and PI3K that are involved in the transcriptional control of the H2-Ab gene, resulting in decreased expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol could directly inhibit the expression of the H2-Ab gene by downregulating the activity of sirtuins and mimicking caloric restriction conditions that are known to repress certain immune functions. | ||||||