GTPBP3 Inhibitors
The chemical class termed GTPBP3 Inhibitors comprises a selection of compounds predominantly targeted at mitochondrial function. Given that GTPBP3 is closely associated with the mitochondria for its role in tRNA modification, affecting mitochondrial function equates to an indirect but measurable impact on GTPBP3's activity. For example, inhibitors of the mitochondrial respiratory chain, such as Phenformin, Rotenone, and IACS-010759, can create an energy-depleted state within the mitochondria, affecting the catalytic function of GTPBP3. Mito-TEMPO, a targeted antioxidant, alters the redox environment of the mitochondrial matrix, offering another angle for modulating GTPBP3's enzymatic activity.
Other agents such as Oligomycin and TTFA disrupt ATP production or complex II of the respiratory chain, respectively, providing further pathways for affecting GTPBP3 indirectly. Additionally, translation inhibitors like Chloramphenicol and Actinonin serve to disrupt the broader mitochondrial translation mechanism. Given that GTPBP3 is involved in tRNA modification-a key step in translation-these agents also play a significant role. Finally, agents that affect mitochondrial membrane like CCCP offer yet another route for influence on GTPBP3's activity. All these compounds collectively constitute the chemical landscape aimed at modulating the activity of GTPBP3 by targeting its associated cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phenformin Hydrochloride | 834-28-6 | sc-219590 | 10 g | $119.00 | 4 | |
As a biguanide, Phenformin inhibits complex I of the mitochondrial respiratory chain, affecting mitochondrial function, which is essential for GTPBP3's role in mitochondrial tRNA modification. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Inhibits mitochondrial complex I, leading to disrupted mitochondrial function. This can limit the energy required for GTPBP3 to conduct tRNA modifications. | ||||||
TEMPOL | 2226-96-2 | sc-200825 | 1 g | $38.00 | 33 | |
This mitochondria-targeted antioxidant can mitigate ROS levels, affecting the mitochondrial matrix where GTPBP3 operates, thereby potentially affecting its enzymatic activity. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $149.00 $12495.00 | 18 | |
By inhibiting ATP synthase, Oligomycin disrupts ATP production in mitochondria, which is critical for GTPBP3's catalytic function. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $90.00 | 10 | |
Known to inhibit mitochondrial ribosome, it affects mitochondrial translation that might interact with GTPBP3’s tRNA modification role. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $37.00 | 1 | |
An inhibitor of succinate dehydrogenase, affecting complex II and thereby potentially affecting mitochondrial function related to GTPBP3. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
As a complex III inhibitor, it hampers electron transfer within the mitochondrial respiratory chain, which can limit the energy source for GTPBP3. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $43.00 $155.00 $393.00 $862.00 $90.00 | 8 | |
Inhibits cytochrome c oxidase in the mitochondrial respiratory chain. This can indirectly affect GTPBP3 by altering mitochondrial energy status. | ||||||
Myxothiazol | 76706-55-3 | sc-507550 | 1 mg | $148.00 | ||
This complex III inhibitor can disrupt electron flow, affecting the mitochondrial environment where GTPBP3 exerts its tRNA modification activity. | ||||||
Actinonin | 13434-13-4 | sc-201289 sc-201289B | 5 mg 10 mg | $170.00 $385.00 | 3 | |
Known to inhibit mitochondrial peptide deformylase, thus impacting mitochondrial translation which is indirectly associated with GTPBP3's function. | ||||||