TEMPOL CAS: 2226-96-2
MF: C9H18NO2
MW: 172.25
A superoxide dismutase mimetic that restores the effects of TNF-α.

TEMPOL (CAS 2226-96-2)

TEMPOL | CAS 2226-96-2 is rated 5.0 out of 5 by 3.
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Synonym: 1-Oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine
Application: A superoxide dismutase mimetic that restores the effects of TNF-α
CAS Number: 2226-96-2
Purity: ≥99%
Molecular Weight: 172.25
Molecular Formula: C9H18NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

TEMPOL is a superoxide dismutase mimetic that belongs to a class of non-thiol-containing radiation protectors, and has the ability to permeate the membrane. In the presence of TEMPOL, cerebral vessel remodeling is blocked and collagen IV mRNA expression levels are elevated in normotensive and hypertensive rat studies. TEMPOL has been shown to restore the oxidative stress and cardiac dysfunction induced by TNF-α and in PC-12 cells has revealed neuroprotective effects. Additionally, it has shown to decrease blood pressure and sympathetic nerve activity in DOCA-salt rat studies.


References

1. Mitchell, J.B., et al. 1991. Arch. Biochem. Biophys. 289: 62-70. PMID: 1654848
2. Xu, H., et al. 2004. Hypertension. 43: 329-334. PMID: 14707156
3. Khattab, M.M., 2006. Eur. J. Pharmacol. 548: 167-173. PMID: 16973155
4. Lipman, T., et al. 2006. Eur. J. Pharmacol. 549: 50-57. PMID: 16989807
5. Mariappan, N., et al. 2007. Am. J. Physiol. Heart Circ. Physiol. 293: H2726-H2737. PMID: 17675574
6. Pires, P.W., et al. 2010. Microvasc Res. PMID: 20600163

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in water (1670 g/l) at 20° C, ethanol (100 mM), methanol, and DMSO (100 mM).
Storage :
Store at room temperature
Melting Point :
69-71° C (lit.)
Boiling Point :
269° C
Density :
1.19 g/cm3
IC50 :
Plasmodium falciparum K1: IC50 = 19 µg/ml; Plasmodium falciparum NF54: IC50 = 27 µg/ml
pK Values :
pKb: 5.15
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
TN8991000
PubChem CID :
137994
Merck Index :
14: 9141
MDL Number :
MFCD00006478
EC Number :
218-760-9
Beilstein Registry :
1422990
SMILES :
CC1(CC(CC(N1[O])(C)C)O)C

Download SDS (MSDS)

Certificate of Analysis

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TEMPOL  Product Citations

See how others have used TEMPOL. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 20 total

PMID: # 30718685  Kornienko, JS.|Smirnova, IS.|Pugovkina, NA.|Ivanova, JS.|Shilina, MA.|Grinchuk, TM.|Shatrova, AN.|Aksenov, ND.|Zenin, VV.|Nikolsky, NN.|Lyublinskaya, OG.| et al. 2019. Sci Rep. 9: 1296.

PMID: # 30990365  Thangaraj, A.|Periyasamy, P.|Guo, ML.|Chivero, ET.|Callen, S.|Buch, S.| et al. 2019. Autophagy.

PMID: # 30535505  Xu, TZ.|Shen, XY.|Sun, LL.|Chen, YL.|Zhang, BQ.|Huang, DK.|Li, WZ.| et al. 2018. Int. J. Mol. Med.

PMID: # 27069531  Salvi, A. et al. 2016. Oxid Med Cell Longev. 2016: 5059043.

PMID: # 27679544  Steiner, I. et al. 2016. Radiol Oncol. 50: 280-8.

PMID: # 27088800  Wen, Z. et al. 2016. J. Clin. Invest. 126: 1953-67.

PMID: # 27778515  Morita, K.|Miyazaki, S.|Numako, C.|Ikeno, S.|Sasaki, R.|Nishimura, Y.|Ogino, C.|Kondo, A.| et al. 2016. Free Radic. Res. 50: 1319-1328.

PMID: # 25793256  Patki, G. et al. 2015. PLoS ONE. 10: e0117498.

PMID: # 25752964  Al-Shboul, O. et al. 2015. Canadian journal of physiology and pharmacology. 93: 405-11.

PMID: # 26000607  Zhang, M. et al. 2015. PloS one. 10: e0127386.

Citations 1 to 10 of 20 total

Is this product cell culture grade?

Asked by: two2igm05
Thank you for your question. TEMPOL, sc-200825, is not cell culture grade.
Answered by: Chemical Support 4
Date published: 2017-04-11

What is the appearance? Is it colorless?

Asked by: chemsd02
Thank you for your question. sc-200825 (TEMPOL, CAS 2226-96-2) is an orange, flaky crystalline solid.
Answered by: Chemical Support 10
Date published: 2017-04-10

What is the long term storage of this product?

Asked by: hawkeye11
Thank you for your question. The compound, sc-200825, is stable for up to 3 years if stored as a powder at -20ºC. If the compound is made into a solution, then it is stable for up to 6 months if stored at -80ºC. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-23
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Rated 5 out of 5 by from Achieve goal! In the experiments, we found that Tempol has been restored to oxidative stress and cardiac dysfunction and TNF- alpha PC-12 cells induce neuroprotection. In addition, it has reduced blood pressure and sympathetic activity in DOCA salt rats
Date published: 2017-02-09
Rated 5 out of 5 by from be used We used in the presence of TEMPOL, cerebral vascular remodeling was blocked and the expression of collagen IV mRNA increased in normal blood pressure and hypertensive rat studies. TEMPOL has been shown to restore oxidative stress and cardiac dysfunction induced by TNF, and has been shown to be neuroprotective in PC-12 cells.
Date published: 2017-02-05
Rated 5 out of 5 by from Worked well in our experiments Worked well in our experiments, happy with purchase.
Date published: 2015-06-10
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