GRB10 Inhibitors
GRB10 inhibitors include a range of compounds that indirectly modulate the activity of GRB10 by targeting various signaling pathways, particularly those related to insulin and IGF-1 signaling. These inhibitors act through different mechanisms, influencing GRB10 activity by altering the upstream or downstream signaling elements of the pathways in which GRB10 is involved. Compounds like LY294002, Wortmannin, and GDC-0941 exemplify this class by inhibiting PI3K, thereby affecting the PI3K/AKT pathway crucial in GRB10's signaling role. Similarly, mTOR inhibitors like Rapamycin, PP242, AZD8055, and Everolimus influence GRB10 indirectly by disrupting mTOR signaling, which is interconnected with GRB10's function in insulin and IGF-1 signaling pathways.
Additionally, AKT inhibitors such as MK-2206, Perifosine, and Triciribine modulate GRB10 activity by targeting AKT signaling, a pathway that interacts with GRB10. MEK inhibitors like PD98059 and U0126 further demonstrate the indirect approach to inhibiting GRB10 by modulating the MAPK/ERK pathway, which may interact with insulin signaling pathways involving GRB10. In essence, GRB10 inhibitors encompass compounds with diverse mechanisms of action, all converging on the modulation of insulin and IGF-1 signaling pathways. By either directly targeting upstream elements of these pathways or indirectly influencing GRB10 activity through pathway cross-talk and signaling interactions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a PI3K inhibitor, can indirectly inhibit GRB10 by disrupting the PI3K/AKT pathway, which is involved in insulin and IGF-1 signaling processes that GRB10 participates in. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a key component in the PI3K/AKT pathway. This inhibition can affect GRB10 indirectly by altering signaling mechanisms in which GRB10 is involved. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $182.00 $332.00 | 67 | |
MK-2206, an AKT inhibitor, potentially modulates GRB10 activity by disrupting the AKT signaling pathway, which interacts with GRB10 in insulin signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, another PI3K inhibitor, may indirectly inhibit GRB10 by affecting the PI3K/AKT signaling pathway, impacting GRB10's role in insulin and IGF-1 signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059, a MEK inhibitor, could indirectly affect GRB10 by modulating the MAPK/ERK pathway, which may interact with insulin signaling pathways involving GRB10. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $57.00 $172.00 | 8 | |
PP242, an mTOR inhibitor, might affect GRB10 indirectly by disrupting mTOR signaling, which is involved in pathways associated with GRB10's function. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $188.00 $327.00 | 1 | |
Perifosine inhibits AKT activation and could indirectly inhibit GRB10 by disrupting AKT-related signaling pathways that GRB10 is involved in. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $104.00 $141.00 | 14 | |
Triciribine, an AKT inhibitor, may impact GRB10 indirectly by inhibiting AKT-mediated signaling pathways, affecting GRB10's role in insulin signaling. | ||||||
GDC-0941 | 957054-30-7 | sc-364498 sc-364498A | 5 mg 10 mg | $188.00 $199.00 | 2 | |
GDC-0941, a PI3K inhibitor, can potentially modulate GRB10 activity indirectly by affecting the PI3K/AKT signaling pathway. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $163.00 $352.00 | 12 | |
AZD8055, an mTOR inhibitor, could indirectly influence GRB10's function by affecting mTOR signaling, which is interconnected with GRB10's signaling pathways. | ||||||