GPR180 활성제

GPR180, also known as G protein-coupled receptor 180, is an orphan receptor that belongs to the family of G protein-coupled receptors (GPCRs). GPCRs are a large and diverse group of membrane proteins that respond to a variety of extracellular signals, including hormones, neurotransmitters, and environmental stimuli, and transduce these signals into cellular responses, often through the activation of intracellular G proteins.

The designation "orphan receptor" indicates that the endogenous ligand, or natural activating molecule, for GPR180 has not been conclusively identified. This lack of information about its ligand greatly limits the understanding of GPR180's physiological and pathophysiological roles. However, the structural features that GPR180 shares with other GPCRs suggest that it could be involved in similar signaling mechanisms once its ligand is discovered.GPR180 is distinct from other GPCRs in its sequence and is classified within its own unique group within the GPCR superfamily. It is encoded by the GPR180 gene and is expressed in various tissues, although its expression pattern and the regulation of its activity are not fully characterized.