GOLPH4 Inhibitors
GOLPH4 Inhibitors encompass chemicals that, while not directly targeting GOLPH4, modify its associated processes of Golgi function, vesicular trafficking, and phosphatidylinositol signaling. GOLPH4's core activity is based around the Golgi to plasma membrane transport, and this means that any compound that disrupts the Golgi apparatus or its vesicular trafficking capabilities can indirectly modulate GOLPH4's function. Compounds like Brefeldin A and Monensin directly disrupt the Golgi apparatus, and their perturbation leads to a cascade of events that will influence the functioning of proteins like GOLPH4.
Similarly, GOLPH4's affinity to PtdIns(4)P anchors its role in vesicular transport. Phosphatidylinositol signaling modulators such as Wortmannin or LY294002 affect this critical lipid signaling pathway. By disrupting phosphatidylinositol dynamics, these compounds can influence GOLPH4's capability to interact with vesicles, thereby potentially altering its role in vesicular trafficking.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Disrupts Golgi apparatus structure and function. By halting Golgi-mediated vesicular trafficking, it can indirectly influence the processes that involve GOLPH4. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Ionophore that disturbs Golgi apparatus function. Affects vesicular transport and thus can modulate the activities in which GOLPH4 is engaged. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3-kinase inhibitor. By modulating phosphatidylinositol signaling, GOLPH4's interaction with PtdIns(4)P can be affected. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibits PI3-kinase and thus alters phosphatidylinositol signaling, potentially influencing GOLPH4's functionality in vesicular trafficking. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Beta-adrenergic antagonist known to affect phosphatidylinositol signaling, potentially impacting GOLPH4's interaction with PtdIns(4)P. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $273.00 | 6 | |
Arf GEF inhibitor. Disrupts Golgi apparatus morphology and vesicular trafficking which can modulate the processes that GOLPH4 participates in. | ||||||
Pitstop 2 | 1419093-54-1 | sc-507418 | 10 mg | $360.00 | ||
Clathrin inhibitor. By affecting clathrin-mediated endocytosis, it can influence vesicular trafficking pathways that GOLPH4 may be associated with. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Inhibitor of dynamin, affecting vesicular trafficking. This alteration can impact the pathways where GOLPH4 operates. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Calcium ionophore disrupting intracellular calcium levels. By influencing vesicular trafficking, it can modulate GOLPH4's roles. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Microtubule disruptor. Affects vesicular transport and thereby can influence the processes that GOLPH4 is associated with. | ||||||