GOLPH4 Antibody (XY-2): sc-101054

GOLPH4 Antibody (XY-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects GOLPH4 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-GOLPH4 antibody (XY-2) is available as the non-conjugated format. GOLPH4, also known as GOLIM4, GIMPC, GPP130, or P138, is a crucial 696 amino acid single-pass type II membrane protein that resides in the Golgi apparatus, specifically localizing to the Golgi stack membrane and the cis and medial Golgi cisternae. GOLPH4 plays a vital role in mediating protein trafficking along the late endosome-bypass pathway, which is essential for the efficient transport of proteins from the early endosome to the Golgi. GOLPH4 features a large C-terminal luminal domain containing potential N- and O-glycosylation sites, which are critical for function and stability. Additionally, GOLPH4′s short N-terminal tail includes a phosphorylation site that may regulate activity and interactions with other proteins, highlighting the significance of post-translational modifications in its role within the Golgi apparatus.

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GOLPH4 Antibody (XY-2) References:

1. Lumenal endosomal and Golgi-retrieval determinants involved in pH-sensitive targeting of an early Golgi protein.  |  Bachert, C., et al. 2001. Mol Biol Cell. 12: 3152-60. PMID: 11598199
2. Expression of Golgi membrane protein p138 is cell cycle-independent and dissociated from centrosome duplication.  |  Doi, K., et al. 2002. Cell Struct Funct. 27: 117-25. PMID: 12207053
3. The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins.  |  Oka, T., et al. 2004. Mol Biol Cell. 15: 2423-35. PMID: 15004235
4. A cycling cis-Golgi protein mediates endosome-to-Golgi traffic.  |  Natarajan, R. and Linstedt, AD. 2004. Mol Biol Cell. 15: 4798-806. PMID: 15331763
5. Both post-Golgi and intra-Golgi cycling affect the distribution of the Golgi phosphoprotein GPP130.  |  Starr, T., et al. 2007. Traffic. 8: 1265-79. PMID: 17605763
6. Sequence and overexpression of GPP130/GIMPc: evidence for saturable pH-sensitive targeting of a type II early Golgi membrane protein.  |  Linstedt, AD., et al. 1997. Mol Biol Cell. 8: 1073-87. PMID: 9201717

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GOLPH4 Antibody (XY-2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-GOLPH4 Antibody (XY-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GOLPH4 Antibody (XY-2) Specifications

Alternate Product Name: GOLPH4

Product Clone Name: XY-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 473-569

Epitope Target: GOLPH4

Epitope Species: human

Product Reactivity/Detection: GOLPH4

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for GOLPH4 Antibody (XY-2): N/A